2. Protein Tyrosine Kinase/RTK
  3. RET
  4. RET-IN-10

RET-IN-10 is a potent inhibitor of RET. RET loss of function mutations leads to Hirschsprung's disease, while its gain of function mutations is associated with a variety of human tumors. RET-IN-10 has the potential for the research of cancer diseases (extracted from patent WO2021135938A1, compound 18).

For research use only. We do not sell to patients.

RET-IN-10 Chemical Structure

RET-IN-10 Chemical Structure

CAS No. : 2662622-44-6

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RET-IN-10 Related Antibodies

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Description

RET-IN-10 is a potent inhibitor of RET. RET loss of function mutations leads to Hirschsprung's disease, while its gain of function mutations is associated with a variety of human tumors. RET-IN-10 has the potential for the research of cancer diseases (extracted from patent WO2021135938A1, compound 18)[1].

Molecular Weight

536.65

Formula

C29H28N8OS
CAS No.
SMILES

N#CC1=C2C(C3=CN=C(N4CCC(CC4)N=[S@](C5=CC=CC=C5)(C)=O)C=C3)=CC(C6=CN(C)N=C6)=CN2N=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RET-IN-10 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RET-IN-102662622-44-6RETHirschsprung's diseasetumorscancerInhibitorinhibitorinhibit

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