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  4. RETRA hydrobromide

RETRA (hydrobromide) is a mutant p53-dependent activator of p73 that can inhibit cancer cells carrying mutant p53. RETRA (hydrobromide) increases the expression level of p73, induces transcriptional activation of several common to transcriptional targets p53 and p73, which leads to mutant p53- and p73-dependent inhibition of tumor growth, reduction of colony formation and induction of effector caspases.

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RETRA hydrobromide Chemical Structure

RETRA hydrobromide Chemical Structure

CAS No. : 1035875-01-4

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RETRA hydrobromide Related Antibodies

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Description

RETRA (hydrobromide) is a mutant p53-dependent activator of p73 that can inhibit cancer cells carrying mutant p53. RETRA (hydrobromide) increases the expression level of p73, induces transcriptional activation of several common to transcriptional targets p53 and p73, which leads to mutant p53- and p73-dependent inhibition of tumor growth, reduction of colony formation and induction of effector caspases[1].

Molecular Weight

350.25

Formula

C11H12BrNO3S2
CAS No.
SMILES

O=C(CSC1=NCCS1)C2=CC=C(C(O)=C2)O.Br
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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RETRA hydrobromide Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RETRA1035875-01-4Othersp73p53cancer cellstranscriptional activationtumor growthcolony formationcaspasesInhibitorinhibitorinhibit

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RETRA hydrobromide
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