2. Apoptosis
  3. MDM-2/p53
  4. 1035875-01-4

1035875-01-4

RETRA hydrobromide Chemical Structure

1035875-01-4

Chemical Structure

  • RETRA hydrobromide
  • CAS No: 1035875-01-4
    Formula: C11H12BrNO3S2
    Molecular Weight: 350.25
  • IUPAC Name: 2-((4,5-dihydrothiazol-2-yl)thio)-1-(3,4-dihydroxyphenyl)ethan-1-one hydrobromide
  • InChIKey: GUNFIDRZOBRQCN-UHFFFAOYSA-N
  • SMILES: O=C(CSC1=NCCS1)C2=CC=C(C(O)=C2)O.Br

Biological Activity: RETRA (hydrobromide) is a mutant p53-dependent activator of p73 that can inhibit cancer cells carrying mutant p53. RETRA (hydrobromide) increases the expression level of p73, induces transcriptional activation of several common to transcriptional targets p53 and p73, which leads to mutant p53- and p73-dependent inhibition of tumor growth, reduction of colony formation and induction of effector caspases[1].

Cat. No. Product Name Purity Description
HY-113843 RETRA hydrobromide RETRA (hydrobromide) is a mutant p53-dependent activator of p73 that can inhibit cancer cells carrying mutant p53. RETRA (hydrobromide) increases the expression level of p73, induces transcriptional activation of several common to transcriptional targets p53 and p73, which leads to mutant p53- and p73-dependent inhibition of tumor growth, reduction of colony formation and induction of effector caspases.

References

[1]. Kravchenko JE, et al. Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6302-7. [Content Brief]

Keywords:

RETRA hydrobromide