2. Anti-infection
  3. HIV
  4. Reverse transcriptase-IN-3

Reverse transcriptase-IN-3 is a pyrimidine-5-carboxamide derivative, acts as an inhibitor of HIV-1. Reverse transcriptase-IN-3 shows potent activity against the HIV-1 wild-type and mutant strains.

For research use only. We do not sell to patients.

Reverse transcriptase-IN-3 Chemical Structure

Reverse transcriptase-IN-3 Chemical Structure

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Reverse transcriptase-IN-3 Related Antibodies

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Description

Reverse transcriptase-IN-3 is a pyrimidine-5-carboxamide derivative, acts as an inhibitor of HIV-1. Reverse transcriptase-IN-3 shows potent activity against the HIV-1 wild-type and mutant strains[1].

IC50 & Target[1]

HIV (IIIB)

8 nM (EC50)

HIV-1 (L100I)

65 nM (EC50)

HIV-1 (K103N)

9 nM (EC50)

HIV-1 (Y181C)

45 nM (EC50)

HIV-1 (Y188L)

35 nM (EC50)

HIV-1 (E138K)

0.734 μM (EC50)

HIV-1 (F227L+V106A)

34 nM (EC50)

HIV-1 (RES056)

42 nM (EC50)

In Vitro

Reverse transcriptase-IN-3 (compound 21c) exhibits the most potent activity (EC50=0.009-0.065 μM) against HIV-1 IIIB (8 nM), L100I (65 nM), K103N (9 nM), Y181C (45 nM), Y188L (35 nM), and RES056 (42 nM), being comparable of Etravirine (HY-90005)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Reverse transcriptase-IN-3 Related Antibodies
Molecular Weight

561.66

Formula

C28H31N7O4S
SMILES

CC1=CC(C#N)=CC(C)=C1OC2=C(C=NC(NC3CCN(CC3)C4=CC=C(C=C4)NS(=O)(C5CC5)=O)=N2)C(N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Reverse transcriptase-IN-3 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Reverse transcriptase-IN-3HIVHuman immunodeficiency virusInhibitorinhibitorinhibit

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Reverse transcriptase-IN-3
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HY-151938
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