RGH-560

Cat. No.: HY-149776: FAQs
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RGH-560 (compound 53) shows highly advanced α7 nAChR positive modulator properties and favorable physicochemical features. RGH-560 has robust procognitive in vivo potential. RGH-560 can be used to study Scopolamine (HY-N0296) -induced amnesia in mice.

For research use only. We do not sell to patients.

RGH-560 Chemical Structure

CAS No. : 2408799-43-7

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Description

In Vivo

RGH-560 (compound 53) (1 mg/kg, 3 mg/kg, 10 mg/kg; Intraperitoneal injection) has significant cognitive-enhancement in Scopolamine(HY-N0296)-induced amnesia in mice. RGH-560 is a medium clearance compound. RGH-560 is non-toxic to mice at doses up to 30 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mice with scopolamine-induced amnesia^[1]
Dosage:	1 mg/kg, 3 mg/kg, 10 mg/kg
Administration:	Intraperitoneal injection (i.p.)
Result:	Reversed the scopolamine-induced cognitive impairment.

Molecular Weight

393.41

Formula

C₂₂H₂₀FN₃O₃

CAS No.

2408799-43-7

SMILES

CN1C=CC2=C1C=CC(CNC(N3CC4(CC(C(C=CC(F)=C5)=C5O4)=O)C3)=O)=C2

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ledneczki I, et al. Optimization of Novel α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulators and the Discovery of a Preclinical Development Candidate Molecule (RGH-560). Journal of Medicinal Chemistry. 2023 Nov. [Content Brief]

RGH-560 Related Classifications

Neurological Disease

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RGH-5602408799-43-7RGH560RGH 560nAChRNicotinic acetylcholine receptorsScopolamine-induced AmnesiaAgonistInhibitorinhibitorinhibit

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