2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. RGH-560

RGH-560 (compound 53) shows highly advanced α7 nAChR positive modulator properties and favorable physicochemical features. RGH-560 has robust procognitive in vivo potential. RGH-560 can be used to study Scopolamine (HY-N0296) -induced amnesia in mice.

For research use only. We do not sell to patients.

RGH-560 Chemical Structure

RGH-560 Chemical Structure

CAS No. : 2408799-43-7

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RGH-560 Related Antibodies

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Description

RGH-560 (compound 53) shows highly advanced α7 nAChR positive modulator properties and favorable physicochemical features. RGH-560 has robust procognitive in vivo potential. RGH-560 can be used to study Scopolamine (HY-N0296) -induced amnesia in mice[1].

In Vivo

RGH-560 (compound 53) (1 mg/kg, 3 mg/kg, 10 mg/kg; Intraperitoneal injection) has significant cognitive-enhancement in Scopolamine(HY-N0296)-induced amnesia in mice. RGH-560 is a medium clearance compound. RGH-560 is non-toxic to mice at doses up to 30 mg/kg[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice with scopolamine-induced amnesia[1]
Dosage: 1 mg/kg, 3 mg/kg, 10 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Reversed the scopolamine-induced cognitive impairment.
Molecular Weight

393.41

Formula

C22H20FN3O3
CAS No.
SMILES

CN1C=CC2=C1C=CC(CNC(N3CC4(CC(C(C=CC(F)=C5)=C5O4)=O)C3)=O)=C2
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References
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RGH-560 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RGH-5602408799-43-7RGH560RGH 560nAChRNicotinic acetylcholine receptorsScopolamine-induced AmnesiaAgonistInhibitorinhibitorinhibit

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