Riboflavin-d₃  (Synonyms: Vitamin B2-d₃; E101-d₃)

Riboflavin-d₃ is the deuterium labeled Riboflavin. Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

379.38

C₁₇H₁₇D₃N₄O₆

83-88-5

Solid

White to yellow

O[C@H]([C@H](O)[C@H](O)CO)CN1C(C=C(C([2H])([2H])[2H])C(C)=C2)=C2N=C(C(N3)=O)C1=NC3=O

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.  [Content Brief]

  [2]. Long, Q., et al., Riboflavin biosynthetic and regulatory factors as potential novel anti-infective drug targets. Chem Biol Drug Des, 2010. 75(4): p. 339-47.  [Content Brief]

  [3]. Zempleni, J., J.R. Galloway, and D.B. McCormick, Pharmacokinetics of orally and intravenously administered riboflavin in healthy humans. Am J Clin Nutr, 1996. 63(1): p. 54-66.  [Content Brief]

  [4]. Bertollo, C.M., et al., Characterization of the antinociceptive and anti-inflammatory activities of riboflavin in different experimental models. Eur J Pharmacol, 2006. 547(1-3): p. 184-91.  [Content Brief]