Riboxin  (Synonyms: IDP)

Riboxin (IDP), an orally active purine derivative-hypoxanthine rlboside, has antihypoxic and antihyperthermic activity. Riboxin also has an antiarrhythmic action in cats, rabbits, and mice with cardiac rhythm disorders induced by Ouabain. Riboxin protects animals against the noxious effects of γ-irradiation^[1][2].

Riboxin (250 mg/kg; p.o.; single dose) increases the swimming duration of the mice, with no significant influence on the strength endurance. At the same condition, Riboxin increases the rate of survival of the experimental animals in the thermal chamber^[1].
Riboxin (50 mg/kg; p.o.; once daily for 6 days) increases the hanging duration of the mice, while has no significant effect on the duration of swimming and running^[1].
Riboxin (100 mg/kg; p.o.; 1 h befor test) has appreciable radio protective effect against γ-irradiation for mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

414.16

C₉H₁₂N₄O₁₁P₂

86-04-4

O[C@@H]1[C@H](O)[C@@H](OP(OP(O)(O)=O)(O)=O)O[C@H]1N2C3=C(C(N=CN3)=O)N=C2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sokolov I K, et al. Adaptogenic effect of riboxin[J]. Pharmaceutical Chemistry Journal, 1980, 14(1): 34-39.

  [2]. Veveris M, et al. Experimental study of the antiarrhythmic effect of riboxin. Farmakol. Neirotropnykh Sredstv (1978), 119-24.