2. Apoptosis
  3. RIP kinase
  4. RIPK1-IN-19

RIPK1-IN-19 (compound 10b) is a selective RIPK1 inhibitor (IC50=15 nM). RIPK1-IN-19 displays potent protective activity in TNFα-induced systemic inflammatory response syndrome (SIRS) model and Imiquimod (IMQ)-induced psoriasis model. RIPK1-IN-19 can be used in research on inflammation and immune system diseases.

For research use only. We do not sell to patients.

RIPK1-IN-19 Chemical Structure

RIPK1-IN-19 Chemical Structure

CAS No. : 2763831-43-0

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Based on 1 publication(s) in Google Scholar

RIPK1-IN-19 Related Antibodies

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Description

RIPK1-IN-19 (compound 10b) is a selective RIPK1 inhibitor (IC50=15 nM). RIPK1-IN-19 displays potent protective activity in TNFα-induced systemic inflammatory response syndrome (SIRS) model and Imiquimod (IMQ)-induced psoriasis model. RIPK1-IN-19 can be used in research on inflammation and immune system diseases[1].

IC50 & Target[1]

RIPK1

15 nM (IC50)

Molecular Weight

496.54

Formula

C28H25FN6O2
CAS No.
Appearance

Solid

Color

Light brown to brown

SMILES

C[C@@H](C1=CC=CC(F)=C1)NC(C2=CN(C3=C2C=C(C=C3)C4=CC5=NC(NC(C6CC6)=O)=NN5C=C4)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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RIPK1-IN-19 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RIPK1-IN-192763831-43-0RIP kinaseReceptor-interacting protein kinasesRIPKinflammationTNFαSIRSImiquimodIMQpsoriasisimmuneInhibitorinhibitorinhibit

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