RM-581

Cat. No.: HY-147526: FAQs
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RM-581, an aminosteroid derivative, has potent anticancer activity in different types of cancer, including high fatality pancreatic cancer. RM-581 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

RM-581 Chemical Structure

CAS No. : 2086809-59-6

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Description

RM-581, an aminosteroid derivative, has potent anticancer activity in different types of cancer, including high fatality pancreatic cancer^[1]. RM-581 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cellular Effect

Cell Line	Type	Value	Description	References
LAPC4	IC₅₀	0.6 μM Compound: RM-581	Antiproliferative activity against human LAPC4 cells assessed as reduction in cell viability after 72 hrs by MTS assay Antiproliferative activity against human LAPC4 cells assessed as reduction in cell viability after 72 hrs by MTS assay	[PMID: 31893547]
LNCaP	IC₅₀	1.2 μM Compound: RM-581	Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability after 72 hrs by MTS assay Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability after 72 hrs by MTS assay	[PMID: 31893547]
MCF7	IC₅₀	2.6 μM Compound: RM-581	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTS assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTS assay	[PMID: 31893547]
OVCAR-3	IC₅₀	5 μM Compound: RM-581	Antiproliferative activity against human OVCAR-3 cells assessed as reduction in cell viability after 72 hrs by MTS assay Antiproliferative activity against human OVCAR-3 cells assessed as reduction in cell viability after 72 hrs by MTS assay	[PMID: 31893547]
PANC-1	IC₅₀	3.9 μM Compound: RM-581	Antiproliferative activity against human PANC-1 cells assessed as reduction in cell viability after 72 hrs by MTS assay Antiproliferative activity against human PANC-1 cells assessed as reduction in cell viability after 72 hrs by MTS assay	[PMID: 31893547]
PC-3	IC₅₀	1.6 μM Compound: RM-581	Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability after 72 hrs by MTS assay Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability after 72 hrs by MTS assay	[PMID: 31893547]
T47D	IC₅₀	0.5 μM Compound: RM-581	Antiproliferative activity against human T47D cells assessed as reduction in cell viability after 72 hrs by MTS assay Antiproliferative activity against human T47D cells assessed as reduction in cell viability after 72 hrs by MTS assay	[PMID: 31893547]

Molecular Weight

646.82

Formula

C₄₀H₄₆N₄O₄

CAS No.

2086809-59-6

SMILES

C[C@@]12[C@](CC[C@@]2(O)C#C)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC(N5CCN(CC5)C([C@H]6N(CCC6)C(C7=NC8=C(C=CC=C8)C=C7)=O)=O)=C(OC)C=C4CC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. René Maltais, et al. Minor chemical modifications of the aminosteroid derivative RM-581 lead to major impact on its anticancer activity, metabolic stability and aqueous solubility. Eur J Med Chem. 2020 Feb 15;188:111990. [Content Brief]

RM-581 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RM-5812086809-59-6RM581RM 581Biochemical Assay ReagentsAminosteroidanticancerpancreaticInhibitorinhibitorinhibit

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RM-581

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RM-581 Related Classifications

Molarity Calculator

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