RNA polymerase II-IN-2

Cat. No.: HY-147917: FAQs
Data Sheet Handling Instructions

Molarity Calculator

RNA polymerase II-IN-2 (compound 20iii) is a potent RNA polymerase II (Pol II) inhibitor with K_i value of 9.5 nM. RNA polymerase II-IN-2 has cytotoxicity against cancer cells, and exhibits 2 and 5 fold toxicity than α-amanitin against CHO and HEK293.

For research use only. We do not sell to patients.

RNA polymerase II-IN-2 Chemical Structure

CAS No. : 2891451-33-3

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description	RNA polymerase II-IN-2 (compound 20iii) is a potent RNA polymerase II (Pol II) inhibitor with K_i value of 9.5 nM. RNA polymerase II-IN-2 has cytotoxicity against cancer cells, and exhibits 2 and 5 fold toxicity than α-amanitin against CHO and HEK293^[1].
IC₅₀ & Target	K_i: 74.1 nM (Pol II)^[1]
Molecular Weight	915.02
Formula	C₄₁H₅₈N₁₀O₁₂S
CAS No.	2891451-33-3
SMILES	O=C([C@H](C(CC)CC)NC(CNC1=O)=O)NCC(N[C@@H]2C(N[C@H](C(N3C[C@@H](C[C@H]3C(N[C@H](C(N[C@H]1CC4=C(S[C@H]2C)NC5=C4C=CC=C5)=O)[C@H]([C@H](CO)O)C)=O)O)=O)CC(N)=O)=O)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (279 KB) Handling Instructions (2659 KB)
References	[1]. Todorovic M, et al. Rationally Designed Amanitins Achieve Enhanced Cytotoxicity. J Med Chem. 2022 Jun 13. [Content Brief]