2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. RNA polymerase II-IN-2

RNA polymerase II-IN-2 (compound 20iii) is a potent RNA polymerase II (Pol II) inhibitor with Ki value of 9.5 nM. RNA polymerase II-IN-2 has cytotoxicity against cancer cells, and exhibits 2 and 5 fold toxicity than α-amanitin against CHO and HEK293.

For research use only. We do not sell to patients.

RNA polymerase II-IN-2 Chemical Structure

RNA polymerase II-IN-2 Chemical Structure

CAS No. : 2891451-33-3

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RNA polymerase II-IN-2 Related Antibodies

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Description

RNA polymerase II-IN-2 (compound 20iii) is a potent RNA polymerase II (Pol II) inhibitor with Ki value of 9.5 nM. RNA polymerase II-IN-2 has cytotoxicity against cancer cells, and exhibits 2 and 5 fold toxicity than α-amanitin against CHO and HEK293[1].

IC50 & Target

Ki: 74.1 nM (Pol II)[1]
Molecular Weight

915.02

Formula

C41H58N10O12S
CAS No.
SMILES

O=C([C@H](C(CC)CC)NC(CNC1=O)=O)NCC(N[C@@H]2C(N[C@H](C(N3C[C@@H](C[C@H]3C(N[C@H](C(N[C@H]1CC4=C(S[C@H]2C)NC5=C4C=CC=C5)=O)[C@H]([C@H](CO)O)C)=O)O)=O)CC(N)=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RNA polymerase II-IN-2 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RNA polymerase II-IN-22891451-33-3DNA/RNA SynthesisanticancercytotoxicityCHOHEK293Inhibitorinhibitorinhibit

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RNA polymerase II-IN-2
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HY-147917
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