Ro 24-5913 (Synonyms: Cinalukast)

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Ro 24-5913 (Cinalukast) is an orally active and potent LTD4 antagonist with an IC₅₀ value of 6.4 nM. Ro 24-5913 can be used for the research of asthma.

For research use only. We do not sell to patients.

Ro 24-5913 Chemical Structure

CAS No. : 128312-51-6

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•Related Small Molecules:

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LTB₄ LTC₄/CysLT₂ LTD₄/CysLT₁ LTE₄

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Purity & Documentation
References
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Description

Ro 24-5913 (Cinalukast) is an orally active and potent LTD4 antagonist with an IC₅₀ value of 6.4 nM. Ro 24-5913 can be used for the research of asthma^[1].

IC₅₀ & Target

IC50: 6.4 nM (LTD4)^[1]

In Vitro

Ro 24-5913 competes with [³H]LTD4 for its binding site in guinea pig lung membranes with an IC₅₀ value of 6.4 nM^[1].
Ro 24-5913 shows effective antagonist efficacy to LTD4-induced contractions with a pK_B value of 9.3^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ro 24-5913 (10 mg/kg i.v. and 100 mg/kg p.o.; once) inhibits LTD4-induced bronchoconstriction in guinea pigs with LD₅₀s of 0.13 and 0.12 mg/kg for i.v. and p.o. respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Guinea pigs^[1]
Dosage:	10 mg/kg
Administration:	Oral gavage; 10 mg/kg once
Result:	Inhibited LTD4-induced bronchoconstnction and antigen-induced bronchoconstnction in guinea pigs.

Molecular Weight

412.55

Formula

C₂₃H₂₈N₂O₃S

CAS No.

128312-51-6

SMILES

OC(C(CC)(CC)CC(NC1=CC=CC(/C=C/C2=NC(C3CCC3)=CS2)=C1)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. O'Donnell M. Ro 24-5913: a potent, specific, orally active LTD4 antagonist. Ann N Y Acad Sci. 1991;629:413-5. [Content Brief]

Ro 24-5913 Related Classifications

Inflammation/Immunology

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ro 24-5913128312-51-6CinalukastLeukotriene Receptororalasthmabronchoconstrictionguinea pigantagonistInhibitorinhibitorinhibit

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