2. Membrane Transporter/Ion Channel
  3. P2X Receptor
  4. Ro-51

Ro-51 is a potent and selective dual P2X3/P2X2/3 antagonist, with IC50 of 2 nM and 5 nM for P2X3 and P2X2/3, respectively. Ro-51 can be used for the research for pain.

For research use only. We do not sell to patients.

Ro-51 Chemical Structure

Ro-51 Chemical Structure

CAS No. : 1050670-85-3

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Based on 1 publication(s) in Google Scholar

Ro-51 Related Antibodies

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Description

Ro-51 is a potent and selective dual P2X3/P2X2/3 antagonist, with IC50 of 2 nM and 5 nM for P2X3 and P2X2/3, respectively. Ro-51 can be used for the research for pain[1][2].

IC50 & Target

IC50: 2 nM (P2X3), 5 nM (P2X2/3)[1]
In Vitro

Ro-51 has highly selective for P2X 3 and P2X 2/3 exhibiting no antagonistic activity at other P2X receptor family members tested (P2X 1 , P2X 2 , P2X 4 , P2X 5 , and P2X 7 ) at concentrations up to 10 μM[1].
RO51 also shows a significant drop in potency on human P2X3 receptors (IC50 = 110.5 and 0.04 nM, respectively for human and rat P2X3)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ro-51 Related Antibodies
In Vivo

Ro-51 suffers rapid clearance, short half-lives, and high protein binding in rat[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat[1]
Dosage: 2 mg/kg (Pharmacokinetic Analysis)
Administration: Oral administration
Result: AUC= 237 ng/h/mL, T 1/2 =1.52 h
Molecular Weight

474.29

Formula

C17H23IN4O4
CAS No.
SMILES

OCC(NC1=NC=C(OC2=CC(I)=C(OC)C=C2C(C)C)C(N)=N1)CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ro-51 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ro-511050670-85-3Ro51Ro 51P2X ReceptorP2XRsP2X(3)P2X(2/3)painhyperalgesiamechanicalallodyniainflammatoryneuropathicmodelsInhibitorinhibitorinhibit

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