RO4988546

Cat. No.: HY-129274: FAQs
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RO4988546 is a negative allosteric modulator (NAM) that targets metabotropic glutamate receptors 2 and 3 (mGlu2, mGlu3). RO4988546 can reduce the binding of [³h]-LY354740 at the positive binding site, while affecting the receptor's G protein coupling and intracellular signaling. RO4988546 can be used in the development of antidepressants and cognitive enhancers.

For research use only. We do not sell to patients.

RO4988546 Chemical Structure

CAS No. : 911114-85-7

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Description	RO4988546 is a negative allosteric modulator (NAM) that targets metabotropic glutamate receptors 2 and 3 (mGlu2, mGlu3). RO4988546 can reduce the binding of [³h]-LY354740 at the positive binding site, while affecting the receptor's G protein coupling and intracellular signaling. RO4988546 can be used in the development of antidepressants and cognitive enhancers^[1].
Molecular Weight	512.38
Formula	C₂₁H₁₀F₆N₄O₃S
CAS No.	911114-85-7
SMILES	O=S(C1=CC(C#CC2=C3N=C(C=C(N3N=C2)C(F)(F)F)C4=CC=C(C=C4)C(F)(F)F)=CN=C1)(O)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (269 KB) Handling Instructions (2659 KB)
References	[1]. Lundström, et al. Structural determinants of allosteric antagonism at metabotropic glutamate receptor 2: mechanistic studies with new potent negative allosteric modulators. British journal of pharmacology 164.2b (2011): 521-537. [Content Brief]

RO4988546 Related Classifications

Neurological Disease

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RO4988546911114-85-7RO 4988546RO-4988546mGluRMetabotropic glutamate receptorsAllosteric modulatorsG proteinantidepressantcognitive enhancersmGlu2mGlu3Inhibitorinhibitorinhibit

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RO4988546

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