2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. RO4988546

RO4988546 is a negative allosteric modulator (NAM) that targets metabotropic glutamate receptors 2 and 3 (mGlu2, mGlu3). RO4988546 can reduce the binding of [3h]-LY354740 at the positive binding site, while affecting the receptor's G protein coupling and intracellular signaling. RO4988546 can be used in the development of antidepressants and cognitive enhancers.

For research use only. We do not sell to patients.

RO4988546 Chemical Structure

RO4988546 Chemical Structure

CAS No. : 911114-85-7

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RO4988546 Related Antibodies

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Description

RO4988546 is a negative allosteric modulator (NAM) that targets metabotropic glutamate receptors 2 and 3 (mGlu2, mGlu3). RO4988546 can reduce the binding of [3h]-LY354740 at the positive binding site, while affecting the receptor's G protein coupling and intracellular signaling. RO4988546 can be used in the development of antidepressants and cognitive enhancers[1].

Molecular Weight

512.38

Formula

C21H10F6N4O3S
CAS No.
SMILES

O=S(C1=CC(C#CC2=C3N=C(C=C(N3N=C2)C(F)(F)F)C4=CC=C(C=C4)C(F)(F)F)=CN=C1)(O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RO4988546 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RO4988546911114-85-7RO 4988546RO-4988546mGluRMetabotropic glutamate receptorsAllosteric modulatorsG proteinantidepressantcognitive enhancersmGlu2mGlu3Inhibitorinhibitorinhibit

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