2. Cell Cycle/DNA Damage TGF-beta/Smad Stem Cell/Wnt Cytoskeleton Epigenetics
  3. ROCK HDAC
  4. ROCK/HDAC-IN-1

ROCK/HDAC-IN-1 (Compound 10h) is an orally active ROCK/HDAC inhibitor. ROCK/HDAC-IN-1 inhibits ROCK1/2 (IC50: 254.9 nM, 58.18 nM) and HDAC1/2/3/6/8 (IC50: 9.09, 8.03, 6.26, 0.41, 7.69 nM). ROCK/HDAC-IN-1 stimulates the activation of DAMPs, specifically Calreticulin (CRT) exposure and HMGB1 release, indicating that it is a potential ICD inducer.. ROCK/HDAC-IN-1 has antiproliferative activity against breast cancer cells (IC50: 0.37 μM for MDA-MB-231 cell), and inhibits tumor growth and activates T cells without apparent toxicity.

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ROCK/HDAC-IN-1 Chemical Structure

ROCK/HDAC-IN-1 Chemical Structure

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ROCK/HDAC-IN-1 Related Antibodies

Top Publications Citing Use of Products

View All ROCK Isoform Specific Products:

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ROCK ROCK1 ROCK2

View All HDAC Isoform Specific Products:

View All Isoforms
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

ROCK/HDAC-IN-1 (Compound 10h) is an orally active ROCK/HDAC inhibitor. ROCK/HDAC-IN-1 inhibits ROCK1/2 (IC50: 254.9 nM, 58.18 nM) and HDAC1/2/3/6/8 (IC50: 9.09, 8.03, 6.26, 0.41, 7.69 nM). ROCK/HDAC-IN-1 stimulates the activation of DAMPs, specifically Calreticulin (CRT) exposure and HMGB1 release, indicating that it is a potential ICD inducer.. ROCK/HDAC-IN-1 has antiproliferative activity against breast cancer cells (IC50: 0.37 μM for MDA-MB-231 cell), and inhibits tumor growth and activates T cells without apparent toxicity[1].

IC50 & Target[1]

ROCK1

254.9 nM (IC50)

ROCK2

58.18 nM (IC50)

HDAC1

9.09 nM (IC50)

HDAC2

8.03 nM (IC50)

HDAC3

6.26 nM (IC50)

HDAC6

0.41 nM (IC50)

HDAC8

7.69 nM (IC50)

Molecular Weight

386.47

Formula

C19H22N4O3S
SMILES

O=C(NCCCCCCC(NO)=O)C1=CC2=CC(C3=CNN=C3)=CC=C2S1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ROCK/HDAC-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ROCK/HDAC-IN-1ROCKHDACRho-associated protein kinaseRho-associated kinaseRho-kinaseROKHistone deacetylasesInhibitorinhibitorinhibit

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