ROCK

ROCK Related Products (65):

By Type:	Pan (9)
By Effects:	Substrate (1) Inhibitors (58) Activators (3)

Cat. No.	Product Name	Effect	Purity

HY-13257

Thiazovivin	Inhibitor	99.57%
Thiazovivin is a potent ROCK inhibitor, which can protect human embryonic stem cells. Thiazovivin improves the efficiency of iPSC generation.

HY-16563

Narciclasine	Activator	99.88%
Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.

HY-15727

Afuresertib	Inhibitor	99.53%
Afuresertib (GSK2110183) is an orally bioavailable, selective, ATP-competitive and potent pan-Akt kinase inhibitor with K_is of 0.08/2/2.6 nM for Akt1/Akt2/Akt3, respectively.

HY-10583G

Y-27632 dihydrochloride (GMP)	Inhibitor
Y-27632 dihydrochloride (GMP) is the GMP level of Y-27632 dihydrochloride (HY-10583). GMP guidelines are used to produce Y-27632 dihydrochloride (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Y-27632 dihydrochloride is an orally active and ATP-competitive ROCK (Rho-kinase) inhibitor with antiepileptic effect.

HY-10067

Y-33075	Inhibitor	99.19%
Y-33075 is a selective ROCK inhibitor derived from Y-27632, and is more potent than Y-27632, with an IC₅₀ of 3.6 nM.

HY-148808

Zelasudil	Inhibitor	99.86%
Zelasudil (RXC007) is an orally active, highly selective small molecule Rho-associated coiled-coil containing protein kinase 2 (ROCK2) inhibitor with anti-fibrotic efficacy. Zelasudil elicits positive immunomodulatory effects in metastatic pancreatic tumors with increase of CD8+ and CD4+ T cell infiltrate into the tumor cortex and reduction in immunosuppressive FOXP3+ regulatory T cells at the tumor border. Zelasudil is promising for research of pancreatic ductal adenocarcinoma.

HY-10583R

Y-27632 (dihydrochloride) (Standard)	Inhibitor
Y-27632 (dihydrochloride) (Standard) is the analytical standard of Y-27632 (dihydrochloride). Y-27632 dihydrochloride is an orally active and ATP-competitive ROCK (Rho-kinase) inhibitor (ROCK-I K_i=220 nM; ROCK-II K_i=300 nM). Y-27632 dihydrochloride shows antiepileptic effects.

HY-121750

CCG-222740	Inhibitor	99.53%
CCG-222740 is an orally active and selective Rho/myocardin-related transcription factor (MRTF) pathway inhibitor. CCG-222740 is also a potent inhibitor of alpha-smooth muscle actin protein expression. CCG-222740 effectively reduces fibrosis in skin and blocks melanoma metastasis.

HY-10069

Y-33075 dihydrochloride	Inhibitor	98.02%
Y-33075 dihydrochloride is a selective ROCK inhibitor with an IC₅₀ of 3.6 nM.

HY-12798B

Netarsudil hydrochloride	Inhibitor	99.77%
Netarsudil hydrochloride (AR-13324 hydrochloride) is a Rho-associated protein kinas (ROCK) and norepinephrine transporter (NET) inhibitor. Netarsudil hydrochloride has effective in intraocular pressure (IOP) reduction.

HY-12798C

AR-13503	Inhibitor	98.21%
AR-13503 (AR-13324 M1 metabolite) is the hydrolytic metabolite of AR-13324 mesylate. AR-13324 is a ROCK kinase and PKC inhibitor with anti-angiogenic and retinal health-improving effects, showing potential for use in retinal disease research.

HY-12798A

Netarsudil dimesylate		99.56%
Netarsudil mesylate (AR-13324 mesylate) is a small-molecule inhibitor of Rho kinase and a norepinephrine transporter; reduces intraocular pressure (IOP) in normotensive monkey eyes.

HY-15727A

Afuresertib hydrochloride	Inhibitor	99.95%
Afuresertib hydrochloride (GSK 2110183 hydrochloride) is an orally bioavailable, selective, ATP-competitive and potent pan-Akt kinase inhibitor with K_is of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively.

HY-16663

ITX3	Inhibitor	98.60%
ITX3 is a specific and nontoxic inhibitor of TrioN (N-terminal GEF domain of the multidomain Trio protein) with an IC₅₀ value of 76 μM. ITX3 can be used for the research of agent.

HY-Y0078

Cinnamyl Alcohol	Inhibitor	99.80%
Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, with anti-obesity activity.

HY-100521

GKI-1	Inhibitor	99.89%
GKI-1 is a Greatwall (GWL) kinase inhibitor with IC₅₀s of 4.9 and 2.5 μM against hGWL^FL and hGWL-KinDom, respectively. GKI-1 robustly inhibits ROCK1 with an IC₅₀ of 11 μM, but only weakly affected PKA.

HY-13257G

Thiazovivin (GMP)	Inhibitor
Thiazovivin (GMP) is Thiazovivin (HY-13257) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Thiazovivin is a potent ROCK inhibitor.

HY-Q22471

ROCK1-IN-1	Inhibitor	98.86%
ROCK1-IN-1 is a ROCK1 inhibitor with a K_i value of 540 nM. ROCK1-IN-1 can be used for the research of hypertension, glaucoma and erectile dysfunction.

HY-12798

Netarsudil	Inhibitor	98.78%
Netarsudil is a Rho kinase (ROCK) and norepinephrine transporter (NET) inhibitor. Netarsudil increases outflow facility in human eyes through multiple mechanisms.

HY-101244

ZINC00881524	Inhibitor	99.26%
ZINC00881524 is a ROCK inhibitor.

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