2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. ROS 234

ROS 234 is a potent H3 antagonist, with a pKB of 9.46 for Guinea-pig ileum H3-receptor, a pKi of 8.90 for Rat cerebral cortex H3-receptor, and a ED50 of 19.12 mg/kg (ip) in ex vivo of Rat cerebral cortex. ROS 234 diaplays poor central access.

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ROS 234 Chemical Structure

ROS 234 Chemical Structure

CAS No. : 184576-87-2

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ROS 234 Related Antibodies

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Description

ROS 234 is a potent H3 antagonist, with a pKB of 9.46 for Guinea-pig ileum H3-receptor, a pKi of 8.90 for Rat cerebral cortex H3-receptor, and a ED50 of 19.12 mg/kg (ip) in ex vivo of Rat cerebral cortex. ROS 234 diaplays poor central access[1][2].

IC50 & Target[1]

rat H3 receptor

8.90 (pKi)

In Vivo

ROS 234 centrally injected, significantly shortens pentobarbital narcosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

241.29

Formula

C13H15N5
CAS No.
SMILES

C1(NCCCC2=CN=CN2)=NC3=CC=CC=C3N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ROS 234 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ROS 234184576-87-2ROS234ROS-234Histamine Receptorguinea-pig ileumRat cerebral cortex HRat cerebral cortexcentral accessInhibitorinhibitorinhibit

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