ROS tracer precursor

Name: ROS tracer precursor
Brand: MedChemExpress
SKU: HY-126712
Rating: 4.5 (1 reviews)

Cat. No.: HY-126712 Purity: 98.56%: FAQs
Data Sheet SDS COA Handling Instructions

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ROS tracer precursor is the precursor of [¹⁸F]ROStrace for the synthesis of ROStrace, which can be used for disease diagnosis.

For research use only. We do not sell to patients.

ROS tracer precursor Chemical Structure

CAS No. : 2153480-20-5

Size	Price	Stock	Quantity
1 mg	USD 388	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 970	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1600	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 3230	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 5330	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 8800	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

ROS tracer precursor is the precursor of [¹⁸F]ROStrace for the synthesis of ROStrace, which can be used for disease diagnosis^[1].

In Vivo

[¹⁸F]ROStrace is a radiotracer for imaging superoxide in vivo with positron emission tomography (PET), in an LPS model of neuroinflammation. [¹⁸F]ROStrace is found to rapidly cross the blood-brain barrier (BBB) and is trapped in the brain of LPS-treated animals. [¹⁸F]ox-ROStrace, the oxidized form of [¹⁸F]ROStrace, does not cross the BBB. [¹⁸F]ROStrace is a suitable radiotracer for imaging superoxide levels in the central nervous system with PET^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

715.85

Formula

C₃₉H₄₅N₃O₈S

CAS No.

2153480-20-5

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(OC(C)(C)C)NC1=CC=C2C3=C(C=C(NC(OC(C)(C)C)=O)C=C3)C(C4=CC=C(OCCOS(=O)(C5=CC=C(C)C=C5)=O)C=C4)N(C)C2=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (139.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3969 mL	6.9847 mL	13.9694 mL
5 mM	0.2794 mL	1.3969 mL	2.7939 mL
10 mM	0.1397 mL	0.6985 mL	1.3969 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.56%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (251 KB) HNMR (281 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Hou C, et al. Development of a Positron Emission Tomography Radiotracer for Imaging Elevated Levels of Superoxide in Neuroinflammation. ACS Chem Neurosci. 2018 Mar 21;9(3):578-586. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.3969 mL	6.9847 mL	13.9694 mL	34.9235 mL
	5 mM	0.2794 mL	1.3969 mL	2.7939 mL	6.9847 mL
	10 mM	0.1397 mL	0.6985 mL	1.3969 mL	3.4924 mL
	15 mM	0.0931 mL	0.4656 mL	0.9313 mL	2.3282 mL
	20 mM	0.0698 mL	0.3492 mL	0.6985 mL	1.7462 mL
	25 mM	0.0559 mL	0.2794 mL	0.5588 mL	1.3969 mL
	30 mM	0.0466 mL	0.2328 mL	0.4656 mL	1.1641 mL
	40 mM	0.0349 mL	0.1746 mL	0.3492 mL	0.8731 mL
	50 mM	0.0279 mL	0.1397 mL	0.2794 mL	0.6985 mL
	60 mM	0.0233 mL	0.1164 mL	0.2328 mL	0.5821 mL
	80 mM	0.0175 mL	0.0873 mL	0.1746 mL	0.4365 mL
	100 mM	0.0140 mL	0.0698 mL	0.1397 mL	0.3492 mL