Royleanone (Synonyms: NSC 122417)

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Royleanone, a diterpenoid isolated from plants, inhibits the proliferation of cancer cells by inducing cell cycle arrest and mitochondria-mediated apoptosis, also inhibits cell migration potential, inhibits mTOR/PI3/AKT signaling pathway in LNCaP prostate cancer cells.

For research use only. We do not sell to patients.

Royleanone Chemical Structure

CAS No. : 6812-87-9

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

mTOR/PI3/AKT^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	30.14 μM Compound: 20	Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
BXPC-3	GI₅₀	51.04 μM Compound: 20	Cytotoxicity against human BxPC3 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human BxPC3 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
HL-60	IC₅₀	> 30 μM Compound: 3	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	[PMID: 23865778]
HL-60	GI₅₀	36.33 μM Compound: 20	Cytotoxicity against human HL60 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human HL60 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
MCF7	IC₅₀	> 30 μM Compound: 3	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 23865778]
MIA PaCa-2	IC₅₀	32.5 μM Compound: 3	Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay	[PMID: 21775156]
MOLT-3	IC₅₀	13.6 μM Compound: 3	Cytotoxicity against human MOLT3 cells after 72 hrs by MTT assay Cytotoxicity against human MOLT3 cells after 72 hrs by MTT assay	[PMID: 23865778]
MRC5	GI₅₀	45.7 μM Compound: 20	Cytotoxicity against human MRC5 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human MRC5 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
PANC-1	GI₅₀	52.55 μM Compound: 20	Cytotoxicity against human PANC1 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human PANC1 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
PC-3	GI₅₀	27.07 μM Compound: 20	Cytotoxicity against human PC3 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human PC3 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
SK-MEL-1	IC₅₀	> 30 μM Compound: 3	Cytotoxicity against human SK-MEL-1 cells after 72 hrs by MTT assay Cytotoxicity against human SK-MEL-1 cells after 72 hrs by MTT assay	[PMID: 23865778]
U-937	IC₅₀	> 30 μM Compound: 3	Cytotoxicity against human U937 cells after 72 hrs by MTT assay Cytotoxicity against human U937 cells after 72 hrs by MTT assay	[PMID: 23865778]

In Vitro

Royleanone (0-200 μM; 48 h) inhibits the viability of LNCaP cancer cells in a dose-dependent manner, with an IC₅₀ of 12.5 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

316.43

Formula

C₂₀H₂₈O₃

CAS No.

6812-87-9

SMILES

O=C1C(C(C)C)=C(O)C(C2=C1CC[C@@]3([H])C(C)(C)CCC[C@]23C)=O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wu X, et al. Royleanone diterpenoid exhibits potent anticancer effects in LNCaP human prostate carcinoma cells by inducing mitochondrial mediated apoptosis, cell cycle arrest, suppression of cell migration and downregulation of mTOR/PI3K/AKT signalling pathway. J BUON. 2018 Jul-Aug;23(4):1055-1060. [Content Brief]

Royleanone Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Royleanone6812-87-9NSC 122417NSC122417NSC-122417mTORAktMammalian target of RapamycinPKBProtein kinase BmTOR/PI3/AKTInhibitorinhibitorinhibit

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