2. Cell Cycle/DNA Damage
  3. Polo-like Kinase (PLK)
  4. RP-1664

RP-1664 is a selective and orally active PLK4 inhibitor. RP-1664 drives potent synthetic lethality in TRIM37-high tumor models in vitro and in vivo. RP-1664 induces both centriole loss and amplification contribute to hypersensitivity of neuroblastoma cells.

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RP-1664 Chemical Structure

RP-1664 Chemical Structure

CAS No. : 2980682-00-4

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RP-1664 Related Antibodies

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Description

RP-1664 is a selective and orally active PLK4 inhibitor. RP-1664 drives potent synthetic lethality in TRIM37-high tumor models in vitro and in vivo. RP-1664 induces both centriole loss and amplification contribute to hypersensitivity of neuroblastoma cells[1].

IC50 & Target[1]

PLK4

 

Molecular Weight

514.55

Formula

C23H24F2N8O2S
CAS No.
SMILES

CC1=CC(NC2=NC(N(C3=C(C=C(C=C3F)S(C)(=O)=O)F)C)=NC(C4=CN(C=N4)C)=C2C5CC5)=NN1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RP-1664 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RP-16642980682-00-4RP1664RP 1664Polo-like Kinase (PLK)PLK4 inhibitorInhibitorinhibitorinhibit

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