RPR-106541

Cat. No.: HY-19218: FAQs
Data Sheet Handling Instructions

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RPR-106541 is a 17-thiosteroid. RPR 106541 has potent glucocorticosteroid activity. RPR 106541 also has demonstrable effects on carbohydrate and lipid metabolism.

For research use only. We do not sell to patients.

RPR-106541 Chemical Structure

CAS No. : 159001-35-1

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•Related Small Molecules:

•Related Proteins:

View All Interleukin Related Isoform Specific Products:

View All Isoforms

IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

Biological Activity
Purity & Documentation
References
Customer Review

Description

RPR-106541 is a 17-thiosteroid. RPR 106541 has potent glucocorticosteroid activity. RPR 106541 also has demonstrable effects on carbohydrate and lipid metabolism^[1].

IC₅₀ & Target

IL-4

IL-5

In Vivo

RPR-106541 significantly inhibits CD4+ T-cell accumulation and eosinophil accumulation within the lungs and simultaneously inhibits expression of mRNA for interleukin (IL)-4 and IL-5 in an experimental rat model of pulmonary inflammation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

456.59

Formula

C₂₄H₃₄F₂O₄S

CAS No.

159001-35-1

SMILES

C[C@@]12[C@@]3(SC)[C@@](O[C@H](O3)CCC)([H])C[C@@]1([H])[C@]4([H])C[C@H](F)C5=CC(CC[C@]5(C)[C@@]4(F)[C@@H](O)C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Miller GK, et al. Chronic effects of the novel glucocorticosteroid RPR 106541 administered to beagle dogs by inhalation. Toxicol Pathol. 2000 Mar-Apr;28(2):226-36. [Content Brief]

RPR-106541 Related Classifications

Metabolic Disease Inflammation/Immunology

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RPR-106541159001-35-1RPR106541RPR 106541Interleukin RelatedILInhibitorinhibitorinhibit

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