RSV/IAV-IN-2

Cat. No.: HY-130627: FAQs
Data Sheet Handling Instructions

Molarity Calculator

RSV/IAV-IN-2 (compound 14c) is a potent and dual inhibitor of RSV/IAV. RSV/IAV-IN-2 has lesser cytotoxicity than the clinical agent, Ribavirin. RSV/IAV-IN-2 has the potential for the research of RSV and/or IAV infections.

For research use only. We do not sell to patients.

RSV/IAV-IN-2 Chemical Structure

CAS No. : 2395007-75-5

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	CC₅₀	> 100 μM Compound: 14'c	Cytotoxicity against HEK293T cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay Cytotoxicity against HEK293T cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay	[PMID: 31734025]
HEp-2	CC₅₀	1828 μM Compound: 14'c	Cytotoxicity against human HEp-2 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay Cytotoxicity against human HEp-2 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay	[PMID: 31734025]

Molecular Weight

356.44

Formula

C₁₉H₂₀N₂O₃S

CAS No.

2395007-75-5

SMILES

CCOC1=CC=CC=C1NC(CSC2=CNC3=C2C=C(OC)C=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (280.55 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8055 mL	14.0276 mL	28.0552 mL
5 mM	0.5611 mL	2.8055 mL	5.6110 mL
10 mM	0.2806 mL	1.4028 mL	2.8055 mL

View the Complete Stock Solution Preparation Table

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang GN, et al. Design and synthesis of 2-((1H-indol-3-yl)thio)-N-phenyl-acetamides as novel dual inhibitors of respiratory syncytial virus and influenza virus A. Eur J Med Chem. 2020;186:111861. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.8055 mL	14.0276 mL	28.0552 mL	70.1380 mL
	5 mM	0.5611 mL	2.8055 mL	5.6110 mL	14.0276 mL
	10 mM	0.2806 mL	1.4028 mL	2.8055 mL	7.0138 mL
	15 mM	0.1870 mL	0.9352 mL	1.8703 mL	4.6759 mL
	20 mM	0.1403 mL	0.7014 mL	1.4028 mL	3.5069 mL
	25 mM	0.1122 mL	0.5611 mL	1.1222 mL	2.8055 mL
	30 mM	0.0935 mL	0.4676 mL	0.9352 mL	2.3379 mL
	40 mM	0.0701 mL	0.3507 mL	0.7014 mL	1.7535 mL
	50 mM	0.0561 mL	0.2806 mL	0.5611 mL	1.4028 mL
	60 mM	0.0468 mL	0.2338 mL	0.4676 mL	1.1690 mL
	80 mM	0.0351 mL	0.1753 mL	0.3507 mL	0.8767 mL
	100 mM	0.0281 mL	0.1403 mL	0.2806 mL	0.7014 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

RSV/IAV-IN-2 Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RSV/IAV-IN-22395007-75-5RSVInfluenza VirusRespiratory syncytial virusIAVcytotoxicityRibavirininfectionInhibitorinhibitorinhibit

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