RTI-118

Cat. No.: HY-111308: FAQs
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RTI-118 is a novel small-molecule neuropeptide S receptor (NPSR) antagonist. RTI-118 can relieve agent addiction including selectively decrease self-administration.

For research use only. We do not sell to patients.

RTI-118 Chemical Structure

CAS No. : 847554-50-1

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Biological Activity
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References
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Description

RTI-118 is a novel small-molecule neuropeptide S receptor (NPSR) antagonist. RTI-118 can relieve agent addiction including selectively decrease self-administration^[1].

In Vitro

RTI-118 (109 nM) has a reduction in antagonist potency at the NPS 107I variant^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

RTI-118 (5-30 mg/kg, intraperitoneal injection; pre-30 minutes) is well tolerated in rats with no significant outward signs of aversion, sedation or toxicity, it also produces a dose-related decrease in food self-administration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rat^[1]
Dosage:	5 mg/kg; 10 mg/kg; 20 mg/kg; 30 mg/kg
Administration:	Intraperitoneal injection; pre-treatment 30 minutes; 5-30 mg/kg
Result:	The effects on the reinstatement of seeking behavior are restricted to doses of 20 mg/kg or less.

Molecular Weight

448.56

Formula

C₂₆H₃₂N₄O₃

CAS No.

847554-50-1

SMILES

O=C(N1CC2N(C(OC2(C3=CC=CC=C3)C4=CC=CC=C4)=O)CC1)NCCN5CCCCC5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Schmoutz CD, et al.Antagonism of the neuropeptide S receptor with RTI-118 decreases cocaine self-administration and cocaine-seeking behavior in rats.Pharmacol Biochem Behav. 2012 Dec;103(2):332-7. [Content Brief]

[2]. Bonano JS,et al. Effects of the neuropeptide S receptor antagonist RTI-118 [Content Brief]

RTI-118 Related Classifications

Neurological Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RTI-118847554-50-1RTI118RTI 118Neuropeptide Y ReceptorNPY receptorself-administrationNPSRdrugaddictionInhibitorinhibitorinhibit

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