RTI 336

Cat. No.: HY-107055: FAQs
Data Sheet Handling Instructions

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RTI 336 is a phenyltropane analog, as well as a potent and selective dopamine transporter (DAT) inhibitor. RTI 336 inhibits addictive agent induced locomotor activity and self-administration in Lewis rats. RTI 336 exhibits inhibitory effects depending on inherent NAc DAT levels.

For research use only. We do not sell to patients.

RTI 336 Chemical Structure

CAS No. : 204069-50-1

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Description

In Vivo

RTI 336 (3 mg/kg; sc; 30 min pretreatment) significantly decreases the number of infusions of addictive agent in Lewis rats^[1].
RTI 336 (3 mg/kg; ip; 30 min pretreatment) decreases response rates (lever presses/s) induced by addictive agent in Lewis rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

429.38

Formula

C₂₄H₂₆Cl₂N₂O

CAS No.

204069-50-1

SMILES

CN1[C@H]2[C@@H](C3=CC(C4=CC=C(C)C=C4)=NO3)[C@@H](C5=CC=C(Cl)C=C5)C[C@@H]1CC2.Cl

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Haile CN, et al. Cocaine self-administration and locomotor activity are altered in Lewis and F344 inbred rats by RTI 336, a 3-phenyltropane analog that binds to the dopamine transporter. Brain Res. 2005 Sep 7;1055(1-2):186-95. [Content Brief]

Animal Administration	MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References	[1]. Haile CN, et al. Cocaine self-administration and locomotor activity are altered in Lewis and F344 inbred rats by RTI 336, a 3-phenyltropane analog that binds to the dopamine transporter. Brain Res. 2005 Sep 7;1055(1-2):186-95. [Content Brief]

RTI 336 Related Classifications

Neurological Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RTI 336204069-50-1RTI336RTI-336Dopamine TransporterDATSLC6A3Inhibitorinhibitorinhibit

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