Ru-TRZ2

Cat. No.: HY-162569: FAQs
Data Sheet Handling Instructions

Molarity Calculator

Ru-TRZ2 is a potent ruthenium-based chemotherapeutic agent. Ru-TRZ2 induces apoptosis and necroptosis. Ru-TRZ2 shows antitumor activity.

For research use only. We do not sell to patients.

Ru-TRZ2 Chemical Structure

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

Ru-TRZ2 is a potent ruthenium-based chemotherapeutic agent. Ru-TRZ2 induces apoptosis and necroptosis. Ru-TRZ2 shows antitumor activity^[1].

In Vitro

Ru-TRZ2 (72 h) induces necroptosis with IC₅₀s of 0.45, 0.24 µM for HCT116, HT29 cells, respectively^[1].
Ru-TRZ2 induces mitochondrial depolarization and apoptotic cell death in HT29 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:	HT29 cells
Concentration:	10 μM
Incubation Time:	24 h
Result:	Induced apoptosis and increased the expression of cleaved PARP.

In Vivo

Ru-TRZ2 (5 mg/kg; i.v.; every 2 days for 10 injections) shows anti-tumor activity in HT29 xenograft mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	8-10 weeks, Male nude mice^[1]
Dosage:	5 mg/kg
Administration:	I.v.; every 2 days for 10 injections
Result:	Decreased the tumor weight in HT29 xenograft mice.

Molecular Weight

1092.98

Formula

C₄₅H₄₃F₆N₄O₇P₂RuS₂

SMILES

FC(F)(F)S(=O)([O-])=O.CN(C(CCC)=O)/N=N/C1=CC=C(C#[N][Ru+2]2([])[P](C3=CC=CC=C3)(C4=CC=CC=C4)CC[P]2(C5=CC=CC=C5)C6=CC=CC=C6)C=C1.FC(F)(F)S(=O)([O-])=O.C7CCCC7

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gonçalves J, et al. Necroptosis induced by ruthenium (II) complexes as mitochondrial disruptors. Cell Death Discov. 2024 May 28;10(1):261. [Content Brief]

Ru-TRZ2 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ru-TRZ2ApoptosisNecroptosisnecroptosisapoptosisantitumorHT29 cellscleaved PARPInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks