2. Metabolic Enzyme/Protease
  3. E1/E2/E3 Enzyme
  4. Rugonersen sodium

Rugonersen sodium  (Synonyms: RG6091 sodium; RO7248824 sodium)

Cat. No.: HY-148130A Purity: 91.12%
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Rugonersen sodium is a locked-nucleic acid (LNA)- modified antisense oligonucleotides (ASOs), and results in reduction of ubiquitin-protein ligase E3A (UBE3A) silencing. Angelman syndrome (AS) sodium is a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A, Rugonersen has been used for AS reasearch.

For research use only. We do not sell to patients.

DNA, d(P-thio)((2′-O,4′-C-methylene)m5rU-(2′-O,4′-C-methylene)m5rU-(2′-O,4′-C-methylene)rA-C-(2′-O,4′-C-methylene)rA-C-T-T-A-A-T-T-A-T-A-C-T-(2′-O,4′-C-methylene)m5rU-(2′-O,4′-C-methylene)m5rC-(2′-O,4′-C-methylene)m5rC), sodium salt

Rugonersen sodium Chemical Structure

CAS No. : 2591588-58-6

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Based on 1 publication(s) in Google Scholar

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Rugonersen sodium Related Antibodies

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Description

Rugonersen sodium is a locked-nucleic acid (LNA)- modified antisense oligonucleotides (ASOs), and results in reduction of ubiquitin-protein ligase E3A (UBE3A) silencing. Angelman syndrome (AS) sodium is a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A, Rugonersen has been used for AS reasearch[1][2].

Molecular Weight

6948.00

Formula

C204H235N63Na19O109P19S19
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Rugonersen (sodium)]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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Rugonersen sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rugonersen2591588-58-6RG6091RO7248824RG 6091RG-6091RO 7248824RO-7248824E1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseAngelman syndromeUBE3A-ATSlong lasting effectcynomolgus monkey AS human pluripotent stem cell neuronsInhibitorinhibitorinhibit

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