(S)-2-Amino-3,3-dimethylbutanoic acid-¹⁸O, d₂ 

(S)-2-Amino-3,3-dimethylbutanoic acid-18O, d2 is a deuterated labeled (S)-2-Amino-3,3-dimethylbutanoic acid^[1]. (S)-2-amino-3,3-dimethylbutanoic acid is a leucine derivative^[2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].
Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

163.24

C₈H₁₅D₂NO¹⁸O

CC(C)(C)[C@H](N(C[2H])C[2H])C(O)=[18O]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.  [Content Brief]