2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. (S)-AMG-628

(S)-AMG-628 (Compound 16q) is the S-isomer of AMG-628 (HY-123374). (S)-AMG-628 is the orally active antagonist for TRPV1, that inhibits the Capsaicin (HY-10448)- and acid-induced Ca2+-influx with IC50 of 7 nM and 5 nM in CHO cell. (S)-AMG-628 ameliorates Capsaicin-induced rats flinching, and reverses the thermal hypersensitivity in CFA-(HY-153808) induced inflammatory pain models.

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(S)-AMG-628 Chemical Structure

(S)-AMG-628 Chemical Structure

CAS No. : 862269-92-9

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(S)-AMG-628 Related Antibodies

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Description

(S)-AMG-628 (Compound 16q) is the S-isomer of AMG-628 (HY-123374). (S)-AMG-628 is the orally active antagonist for TRPV1, that inhibits the Capsaicin (HY-10448)- and acid-induced Ca2+-influx with IC50 of 7 nM and 5 nM in CHO cell. (S)-AMG-628 ameliorates Capsaicin-induced rats flinching, and reverses the thermal hypersensitivity in CFA-(HY-153808) induced inflammatory pain models[1].

Molecular Weight

492.57

Formula

C25H25FN6O2S
CAS No.
SMILES

CC(NC1=NC(C(S1)=CC=C2)=C2OC3=NC=NC(N4CCN(CC4)[C@H](C5=CC=C(C=C5)F)C)=C3)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(S)-AMG-628 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-AMG-628862269-92-9TRP ChannelTransient receptor potential channelsorally activeflinch modelratCHOhypersensitivityInhibitorinhibitorinhibit

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