S-Benzyl-DL-cysteine-2,3,3-d₃ 

S-Benzyl-DL-cysteine-2,3,3-d₃ is a deuterium labeled Benzylcysteine. Benzylcysteine is an ASCT2 inhibitor that binds to ASCT2 with an apparent Ki of 780 μM. Benzylcysteine inhibit ASCT2 function based on a competitive mechanism, indicating that Benzylcysteine binds to the substrate-binding site of ASCT2[1].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

214.30

C₁₀H₁₀D₃NO₂S

51494-04-3

Solid

White to off-white

NC(C([2H])([2H])SCC1=CC=CC=C1)([2H])C(O)=O

Room temperature in continental US; may vary elsewhere.

• [1]. Christof Grewer, et al. New inhibitors for the neutral amino acid transporter ASCT2 reveal its Na+-dependent anion leak. J Physiol. 2004 Jun 15;557(Pt 3):747-59.  [Content Brief]