2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. (S,R,S)-AHPC-C1-Br

(S,R,S)-AHPC-C1-Br is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used in PROTAC technology.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-C1-Br Chemical Structure

(S,R,S)-AHPC-C1-Br Chemical Structure

CAS No. : 2379404-33-6

Size Price Stock Quantity
1 mg USD 145 In-stock
5 mg USD 430 In-stock
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50 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

(S,R,S)-AHPC-C1-Br Related Antibodies

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor

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Description

(S,R,S)-AHPC-C1-Br is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used in PROTAC technology[1].

IC50 & Target

VHL

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S,R,S)-AHPC-C1-Br Related Antibodies
Molecular Weight

551.50

Formula

C24H31BrN4O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

BrCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (226.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8132 mL 9.0662 mL 18.1324 mL
5 mM 0.3626 mL 1.8132 mL 3.6265 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8132 mL 9.0662 mL 18.1324 mL 45.3309 mL
5 mM 0.3626 mL 1.8132 mL 3.6265 mL 9.0662 mL
10 mM 0.1813 mL 0.9066 mL 1.8132 mL 4.5331 mL
15 mM 0.1209 mL 0.6044 mL 1.2088 mL 3.0221 mL
20 mM 0.0907 mL 0.4533 mL 0.9066 mL 2.2665 mL
25 mM 0.0725 mL 0.3626 mL 0.7253 mL 1.8132 mL
30 mM 0.0604 mL 0.3022 mL 0.6044 mL 1.5110 mL
40 mM 0.0453 mL 0.2267 mL 0.4533 mL 1.1333 mL
50 mM 0.0363 mL 0.1813 mL 0.3626 mL 0.9066 mL
60 mM 0.0302 mL 0.1511 mL 0.3022 mL 0.7555 mL
80 mM 0.0227 mL 0.1133 mL 0.2267 mL 0.5666 mL
100 mM 0.0181 mL 0.0907 mL 0.1813 mL 0.4533 mL
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(S,R,S)-AHPC-C1-Br Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,R,S)-AHPC-C1-Br2379404-33-6E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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