(S,R,S)-AHPC-C6-NH2 dihydrochloride (Synonyms: VH032-C6-NH2 dihydrochloride)

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(S,R,S)-AHPC-C6-NH2 dihydrochloride (VH032-C6-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader. (S,R,S)-AHPC-C6-NH2 dihydrochloride is XF038-161A, example 6, extracted from patent WO2019173516A1.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-C6-NH2 dihydrochloride Chemical Structure

CAS No. : 2341796-77-6

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Other Forms of (S,R,S)-AHPC-C6-NH2 dihydrochloride:

(S,S,R)-AHPC-C6-NH2 Get quote
(S,R,S)-AHPC-C6-NH2 hydrochloride Get quote
(S,R,S)-AHPC-C6-NH2 Get quote

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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Description

IC₅₀ & Target^[1]

VHL

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

630.67

Formula

C₂₉H₄₅Cl₂N₅O₄S

CAS No.

2341796-77-6

SMILES

[H]Cl.[H]Cl.O=C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)[C@H](C(C)(C)C)NC(CCCCCCN)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Jian Jin, et al. Serine threonine kinase (akt) degradation / disruption compounds and methods of use. Patent WO2019173516A1.

(S,R,S)-AHPC-C6-NH2 dihydrochloride Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,R,S)-AHPC-C6-NH22341796-77-6VH032-C6-NH2E3 Ligase Ligand-Linker ConjugatesAKTdegradationXF038-161APROTACrheumatoid arthritisosteoarthritisCrohn’sdiseaseangiofibromaretinalvascularizationdiabetic retinopathyInhibitorinhibitorinhibit

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