2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. (S,R,S)-AHPC-Me-C5-COOH

(S,R,S)-AHPC-Me-C5-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C5-COOH can be used in PROTAC DT2216 (HY-130604).

For research use only. We do not sell to patients.

(S,R,S)-AHPC-Me-C5-COOH Chemical Structure

(S,R,S)-AHPC-Me-C5-COOH Chemical Structure

CAS No. : 2229976-21-8

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Based on 1 publication(s) in Google Scholar

(S,R,S)-AHPC-Me-C5-COOH Related Antibodies

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

(S,R,S)-AHPC-Me-C5-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C5-COOH can be used in PROTAC DT2216 (HY-130604)[1].

IC50 & Target[1]

VHL

 

In Vitro

DT2216 is a selective B-cell lymphoma extra large (BCL-XL) PROTAC degrader[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S,R,S)-AHPC-Me-C5-COOH Related Antibodies
Molecular Weight

586.74

Formula

C30H42N4O6S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N[C@H](C1=CC=C(C2=C(C)N=CS2)C=C1)C)[C@H]3N(C([C@H](C(C)(C)C)NC(CCCCCC(O)=O)=O)=O)C[C@H](O)C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (170.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7043 mL 8.5217 mL 17.0433 mL
5 mM 0.3409 mL 1.7043 mL 3.4087 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7043 mL 8.5217 mL 17.0433 mL 42.6083 mL
5 mM 0.3409 mL 1.7043 mL 3.4087 mL 8.5217 mL
10 mM 0.1704 mL 0.8522 mL 1.7043 mL 4.2608 mL
15 mM 0.1136 mL 0.5681 mL 1.1362 mL 2.8406 mL
20 mM 0.0852 mL 0.4261 mL 0.8522 mL 2.1304 mL
25 mM 0.0682 mL 0.3409 mL 0.6817 mL 1.7043 mL
30 mM 0.0568 mL 0.2841 mL 0.5681 mL 1.4203 mL
40 mM 0.0426 mL 0.2130 mL 0.4261 mL 1.0652 mL
50 mM 0.0341 mL 0.1704 mL 0.3409 mL 0.8522 mL
60 mM 0.0284 mL 0.1420 mL 0.2841 mL 0.7101 mL
80 mM 0.0213 mL 0.1065 mL 0.2130 mL 0.5326 mL
100 mM 0.0170 mL 0.0852 mL 0.1704 mL 0.4261 mL
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(S,R,S)-AHPC-Me-C5-COOH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,R,S)-AHPC-Me-C5-COOH2229976-21-8E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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Product Name:
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