(S,R,S)-MI-1061

Cat. No.: HY-125858B: FAQs
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(S,R,S)-MI-1061 is the isomer of MI-1061(HY-125858). (S,R,S)-MI-1061 can used to synthesize Antibody-Drug Conjugates (ADCs). MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC₅₀=4.4 nM; K_i=0.16 nM). MI-1061 potently activates p53 and induces apoptosis in the SJSA-1 xenograft tumor tissue in mice. Anti-tumor activity.

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(S,R,S)-MI-1061 Chemical Structure

CAS No. : 1410738-90-7

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Other Forms of (S,R,S)-MI-1061:

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Description	(S,R,S)-MI-1061 is the isomer of MI-1061(HY-125858). (S,R,S)-MI-1061 can used to synthesize Antibody-Drug Conjugates (ADCs). MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC₅₀=4.4 nM; K_i=0.16 nM). MI-1061 potently activates p53 and induces apoptosis in the SJSA-1 xenograft tumor tissue in mice. Anti-tumor activity^[1].
Molecular Weight	582.45
Formula	C₃₀H₂₆Cl₂FN₃O₄
CAS No.	1410738-90-7
SMILES	O=C1[C@@]2(C3=CC=C(Cl)C=C3N1)C4(CCCCC4)N[C@@H]([C@H]2C5=C(C(Cl)=CC=C5)F)C(NC6=CC=C(C=C6)C(O)=O)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (272 KB) Handling Instructions (2659 KB)
References	[1]. Nathan FISHKIN, et al. Linkers for use in antibody drug conjugates. WO2023037268A1.

(S,R,S)-MI-1061 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,R,S)-MI-10611410738-90-7Drug-Linker Conjugates for ADCMDM-2/p53MI-1061isomerInhibitorinhibitorinhibit

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(S,R,S)-MI-1061

Other Forms of (S,R,S)-MI-1061:

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