(S)-V-0219 

(S)-V-0219 is an enantiomer of V-0219 (HY-143312). V-0219 is an orally active and positive allosteric modulator (PAM) of the GLP Receptor-1 (GLP-1R). (S)-V-0219 activates calcium fluxes in HEK cells stably expressing hGLP-1R. (S)-V-0219 is orally active and ameliorates high glucose levels in mice and inhibits feeding behavior in fasted mice^[1].

GLP-1R^[1]

(S)-V-0219 ((S)-9) (0.1 nM) potentiates calcium fluxes in HEK cells stably expressing hGLP-1R^[1].
(S)-V-0219 (0.1 nM) potentiates insulin secretion stimulated by GLP-1 in the stable human pancreatic cell line EndoC-βH1 under high glucose concentration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S)-V-0219 ((S)-9) (0.04-0.2 mg/kg; i.p.) improves glucose handling after injection of 2 g/kg glucose in normal male Wistar rats^[1].
(S)-V-0219 (0. 4 mg/kg; i.g.) is orally active in fatty diabetic Zucker rats^[1].
(S)-V-0219 (0.1-5 μg/kg in 5 μL; i.c.v.) decreases feeding in 12-h fasted male Wistar rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

410.43

C₂₀H₂₅F₃N₄O₂

3031984-78-5

FC(C1=CC=C(C2=NOC(CN3C[C@H](CN4CCOCC4)CCC3)=N2)C=C1)(F)F

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Decara JM, et, al. Discovery of V-0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor toward Oral Treatment for "Diabesity". J Med Chem. 2022 Apr 14;65(7):5449-5461.  [Content Brief]