2. Cell Cycle/DNA Damage Anti-infection
  3. ClpP Bacterial
  4. (S)-ZG197

(S)-ZG197 is a highly selective Staphylococcus aureus Caseinolytic protease P (SaClpP) activator with an EC50 of 1.4 μM.

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(S)-ZG197 Chemical Structure

(S)-ZG197 Chemical Structure

CAS No. : 2999672-66-9

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(S)-ZG197 Related Antibodies

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Description

(S)-ZG197 is a highly selective Staphylococcus aureus Caseinolytic protease P (SaClpP) activator with an EC50 of 1.4 μM[1].

IC50 & Target

EC50: 1.4 μM (SaClpP)[1]
Kd: 5.0 μM (SaClpP)[1]
In Vitro

(S)-ZG197 (10 μM; 2 h) increases the melting temperature (Tm) of SaClpP but barely changes the Tm of HsClpP. (S)-ZG197 significantly increases thermal stability of SaClpP[1].
(S)-ZG197 (0.1-100 μM; 2 h) exhibits a significantly diminished activity on the SaClpPI91W mutant for α-casein hydrolysis[1].
(S)-ZG197 (10 μM; 2 h) fails to induce the Tm shift of SaClpPI91W in intact staphylococcal cells[1].
(S)-ZG197 (0-256 μg/mL; 18 h) inhibits the growth of S. aureus 8325-4, and the MIC is 4 μg/mL. (S)-ZG197 displays strong antibacterial activity on a broad spectrum of S. aureus strains, with MIC values of 2-8 μg/mL[1].
(S)-ZG197 (0-20 μM) decrease SaFtsZ abundance in the 8325-4 S. aureus but not in the corresponding ΔclpP mutant strain[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S)-ZG197 Related Antibodies

Western Blot Analysis[1]

Cell Line: Cell lysates of S. aureus 8325-4 clpP knockout (ΔclpP) strain
Concentration: 0, 2.5, 5 and 10 μM
Incubation Time: 15 min
Result: SaFtsZ protein was degraded when SaClpP was added.
In Vivo

(S)-ZG197 (25-100 mg/kg; i.p.; once) significantly prolong the survival rate in zebrafish USA300 infection model[1].
(S)-ZG197 (7.5 mg/kg; s.c.; twice a day for 3 days) shows anti-infective efficacy in murine skin S. aureus infection models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Zebrafish USA300 infection model[1]
Dosage: 25, 50, or 100 mg/kg
Administration: Intraperitoneal injection, single dose
Result: Significantly prolong the survival rate at 50 mg/kg. Lost therapeutic effects on zebrafish infected with the ΔclpP mutant strain.
Animal Model: Female BALB/c mice, S. aureus infection model[1]
Dosage: 7.5 mg/kg
Administration: Subcutaneous injection, twice a day for 3 days
Result: Caused a smaller necrotic lesion size in mice compared with the vehicle control.
Molecular Weight

532.60

Formula

C28H35F3N4O3
CAS No.
SMILES

O=C(N1CCC(N([C@H]2[C@@H](C)CC)[C@]1([H])CN([C@@H](C)C3=C(C=CC=C4)C4=CC=C3)C2=O)=O)NCCCC(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(S)-ZG197 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-ZG1972999672-66-9ClpPBacterialCaseinolytic protease PSaClpPHsClpPS. aureuszebrafishUSA300BALB/c miceInhibitorinhibitorinhibit

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