S186

Cat. No.: HY-13950 Purity: 99.01%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

S186 is a kind of sodium salts of calcium-acetylpropylamine phosphonate(APA); a new strontium-specific chelating agent.

For research use only. We do not sell to patients.

S186 Chemical Structure

CAS No. : 97759-16-5

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	USD 363	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 363	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 105	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 270	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 430	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 800	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1120	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1680	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Biological Activity
Purity & Documentation
References
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Description

S186 is a kind of sodium salts of calcium-acetylpropylamine phosphonate(APA); a new strontium-specific chelating agent. IC50 value: Target: In a case test for 4 person who took 90Sr in due to an internal contaminated accident, the APAP was adminstrated intramuscularly once a day for 3 days, the increase excretion of 90Sr was obvious and no side effects was observed among them. Recently, S186 has also been approved by Shanghai Municipal Health Bureau for emergency medical use in China.

Molecular Weight

321.15

Formula

C₅H₁₀CaNNaO₇P₂

CAS No.

97759-16-5

Appearance

Solid

Color

White to off-white

SMILES

O=C(C)NC(CC)(P([O-])([O-])=O)P(O)(O[Na])=O.[Ca+2]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 25 mg/mL (77.85 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1138 mL	15.5690 mL	31.1381 mL
5 mM	0.6228 mL	3.1138 mL	6.2276 mL
10 mM	0.3114 mL	1.5569 mL	3.1138 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.01%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (253 KB) RP-HPLC (95 KB) MS (133 KB)

Handling Instructions (2659 KB)

References

[1]. Weihai Zhuo, et al. A Brief Review of Researches Related to Radiation Emergency Medicine at Fundan University, China. Radiation Emergency Medicine. 2012 Vol.1 No.1-2 7-10.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.1138 mL	15.5690 mL	31.1381 mL	77.8452 mL
	5 mM	0.6228 mL	3.1138 mL	6.2276 mL	15.5690 mL
	10 mM	0.3114 mL	1.5569 mL	3.1138 mL	7.7845 mL
	15 mM	0.2076 mL	1.0379 mL	2.0759 mL	5.1897 mL
	20 mM	0.1557 mL	0.7785 mL	1.5569 mL	3.8923 mL
	25 mM	0.1246 mL	0.6228 mL	1.2455 mL	3.1138 mL
	30 mM	0.1038 mL	0.5190 mL	1.0379 mL	2.5948 mL
	40 mM	0.0778 mL	0.3892 mL	0.7785 mL	1.9461 mL
	50 mM	0.0623 mL	0.3114 mL	0.6228 mL	1.5569 mL
	60 mM	0.0519 mL	0.2595 mL	0.5190 mL	1.2974 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

S186 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S18697759-16-5S 186S-186OthersInhibitorinhibitorinhibit

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