Cutamesine (Synonyms: SA4503; AGY 94806)

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Cutamesine (SA4503; AGY-94806) is a selective sigma 1 receptor(σ1R) agonist; high affinity for the sigma 1 receptor (IC50= 17.4±1.9 nM); 100-fold less affinity for the sigma 2 receptor.

For research use only. We do not sell to patients.

Cutamesine Chemical Structure

CAS No. : 165377-43-5

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This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Cutamesine:

Cutamesine dihydrochloride

Other Forms of Cutamesine:

Cutamesine dihydrochloride In-stock

3 Publications Citing Use of MCE Cutamesine

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Sigma 1 Receptor Sigma 2 Receptor

Biological Activity
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Description

Cutamesine (SA4503; AGY-94806) is a selective sigma 1 receptor(σ1R) agonist; high affinity for the sigma 1 receptor (IC50= 17.4±1.9 nM); 100-fold less affinity for the sigma 2 receptor.

IC₅₀ & Target

Sigma 1 Receptor

Clinical Trial

Molecular Weight

368.51

Formula

C₂₃H₃₂N₂O₂

CAS No.

165377-43-5

SMILES

COC1=CC=C(CCN2CCN(CCCC3=CC=CC=C3)CC2)C=C1OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Matsuno K, et al. Binding properties of SA4503, a novel and selective sigma 1 receptor agonist. Eur J Pharmacol. 1996 Jun 13;306(1-3):271-9. [Content Brief]

[2]. Minabe Y, et al. Acute and chronic administration of the selective sigma1 receptor agonist SA4503 significantly alters the activity of midbrain dopamine neurons in rats: An in vivo electrophysiological study. Synapse. 1999 Aug;33(2):129-40. [Content Brief]

[3]. Ono Y, et al. SA4503, a sigma-1 receptor agonist, suppresses motor neuron damage in in vitro and in vivo amyotrophic lateral sclerosis models. Neurosci Lett. 2014 Jan 24;559:174-8. [Content Brief]

Cutamesine Related Classifications

Neurological Disease

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cutamesine165377-43-5SA4503 AGY 94806SA 4503SA-4503AGY94806AGY 94806AGY-94806Sigma ReceptorInhibitorinhibitorinhibit

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