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Samalizumab  (Synonyms: ALXN 6000)

Cat. No.: HY-P99400 Purity: 99.81%
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Samalizumab (ALXN 6000) is a humanized monoclonal antibody that specifically binds to CD200 and blocks its ligation to the CD200 receptor (CD200R). Samalizumab can be used for multiple myeloma and B-cell chronic lymphocytic leukemia research.

For research use only. We do not sell to patients.

CAS No. : 1073059-33-2

Size Price Stock Quantity
1 mg USD 300 In-stock
5 mg USD 780 In-stock
10 mg USD 1450 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Samalizumab (ALXN 6000) is a humanized monoclonal antibody that specifically binds to CD200 and blocks its ligation to the CD200 receptor (CD200R). Samalizumab can be used for multiple myeloma and B-cell chronic lymphocytic leukemia research[1].

Isotype

IgG2-G4 kappa
Species

Humanized

In Vitro

Samalizumab is rationally engineered with an Ig G2/G4 constant region to minimize effector function and preserve immune cell subsets. Samalizumab is a first-in-class, recombinant humanized anti-CD200 mAb, engineered to ablate effector function, that specifically binds to the immune checkpoint CD200, blocks receptor engagement and signaling and antagonizes CD200-driven immune suppression, thereby mount an anti-tumor immune response[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Samalizumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • IgG2-G4-kappa
Biological Activity
  • Immobilized CD200 Protein (His Tag), Human can bind Samalizumab. The EC50 for this effect is 1.53 ng/mL.
Purity & Documentation
References
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Samalizumab Related Classifications

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Keywords:

Samalizumab1073059-33-2ALXN 6000ALXN6000ALXN-6000Othershumanized monoclonal antibodyCD200multiple myelomaB-cell chronic lymphocytic leukemiaInhibitorinhibitorinhibit

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