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Samalizumab  (Synonyms: ALXN 6000)

Cat. No.: HY-P99400 Purity: 99.81%
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Samalizumab (ALXN 6000) is a humanized monoclonal antibody that specifically binds to CD200 and blocks its ligation to the CD200 receptor (CD200R). Samalizumab can be used for multiple myeloma and B-cell chronic lymphocytic leukemia research.

For research use only. We do not sell to patients.

CAS No. : 1073059-33-2

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Based on 1 publication(s) in Google Scholar

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Samalizumab Related Antibodies

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1 Publications Citing Use of MCE Samalizumab

  • Biological Activity

  • Purity & Documentation

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Description

Samalizumab (ALXN 6000) is a humanized monoclonal antibody that specifically binds to CD200 and blocks its ligation to the CD200 receptor (CD200R). Samalizumab can be used for multiple myeloma and B-cell chronic lymphocytic leukemia research[1].

Isotype

IgG4 kappa
Recommend Isotype Controls
Species

Humanized

In Vitro

Samalizumab is rationally engineered with an Ig G2/G4 constant region to minimize effector function and preserve immune cell subsets. Samalizumab is a first-in-class, recombinant humanized anti-CD200 mAb, engineered to ablate effector function, that specifically binds to the immune checkpoint CD200, blocks receptor engagement and signaling and antagonizes CD200-driven immune suppression, thereby mount an anti-tumor immune response[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Samalizumab Related Antibodies
Clinical Trial
Molecular Weight

144840.00

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Samalizumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
Biological Activity
  • Immobilized CD200 Protein (His Tag), Human can bind Samalizumab. The EC50 for this effect is 1.53 ng/mL.
Purity & Documentation
References
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Samalizumab Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Samalizumab1073059-33-2ALXN 6000ALXN6000ALXN-6000Othershumanized monoclonal antibodyCD200multiple myelomaB-cell chronic lymphocytic leukemiaInhibitorinhibitorinhibit

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