2. Apoptosis
  3. Apoptosis
  4. Sampangine

Sampangine is an alkaloid that induces apoptosis by inducing cell cycle arrest in the G0/G1 phase. Sampangine can inhibit the biosynthesis of heme.

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Sampangine Chemical Structure

Sampangine Chemical Structure

CAS No. : 116664-93-8

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Sampangine Related Antibodies

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Description

Sampangine is an alkaloid that induces apoptosis by inducing cell cycle arrest in the G0/G1 phase. Sampangine can inhibit the biosynthesis of heme[1][2].

Cellular Effect
Cell Line Type Value Description References
A2780 IC50
0.6 μM
Compound: 6
Antiproliferative activity against human A2780 cells after 2 days by Alamar Blue assay
Antiproliferative activity against human A2780 cells after 2 days by Alamar Blue assay
[PMID: 21504145]
BT-549 IC50
6.4 μg/mL
Compound: 4
Cytotoxicity against human BT549 cells after 2 to 7 days by neutral red assay
Cytotoxicity against human BT549 cells after 2 to 7 days by neutral red assay
[PMID: 11374943]
HeLa IC50
> 10 μg/mL
Compound: 4
Inhibition of LFA1/ICAM1-mediated CFSE-labeled TPA-stimulated human HL60 cell adhesion to ICAM1 expressing human HeLa cells after 45 mins by fluorescence analysis
Inhibition of LFA1/ICAM1-mediated CFSE-labeled TPA-stimulated human HL60 cell adhesion to ICAM1 expressing human HeLa cells after 45 mins by fluorescence analysis
[PMID: 11374943]
HL-60 IC50
2 μg/mL
Compound: 4
Cytotoxicity against human HL60 cells after 7 days by XTT/PMS assay
Cytotoxicity against human HL60 cells after 7 days by XTT/PMS assay
[PMID: 11374943]
KB IC50
5.3 μg/mL
Compound: 4
Cytotoxicity against human KB cells after 2 to 7 days by neutral red assay
Cytotoxicity against human KB cells after 2 to 7 days by neutral red assay
[PMID: 11374943]
NCI-H460 IC50
0.58 μM
Compound: 6
Antiproliferative activity against human H460 cells after 96 hrs by Cell Titre-Glo luminescent assay
Antiproliferative activity against human H460 cells after 96 hrs by Cell Titre-Glo luminescent assay
[PMID: 21504145]
SK-MEL IC50
0.37 μg/mL
Compound: 4
Cytotoxicity against human SK-MEL cells after 2 to 7 days by neutral red assay
Cytotoxicity against human SK-MEL cells after 2 to 7 days by neutral red assay
[PMID: 11374943]
SK-OV-3 IC50
4.1 μg/mL
Compound: 4
Cytotoxicity against human SKOV3 cells after 2 to 7 days by neutral red assay
Cytotoxicity against human SKOV3 cells after 2 to 7 days by neutral red assay
[PMID: 11374943]
Molecular Weight

232.24

Formula

C15H8N2O
CAS No.
SMILES

O=C1C2=NC=CC3=CC=NC(C4=C1C=CC=C4)=C32
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Sampangine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sampangine116664-93-8Apoptosisheme biosynthesisHL-60alkaloidInhibitorinhibitorinhibit

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