SAMT-247 

SAMT-247 is a microbicide that selectively inactivate the viral nucleocapsid protein NCp7, causing zinc ejection and preventing RNA encapsidation. SAMT-247 shows good antiviral activity^[1][2].

SAMT-247 covalently modifies the Gag polyprotein^[2].
SAMT-247 shows antiviral activity with an EC₅₀ of 0.6 μM in CEM-SS cells infected with HIV-1_IIIB. SAMT-247 shows low cellular toxicity (TC₅₀ > 100 μM)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

A 1% gel formulation of SAMT-247 protected five of six rhesus macaques from vaginal challenge with a CCR5 (R5) -tropic SHIV^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

266.32

C₁₂H₁₄N₂O₃S

850715-59-2

CC(SC1=CC=CC=C1C(NCCC(N)=O)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Helmold Hait S, et al. An SAMT-247 Microbicide Provides Potent Protection against Intravaginal Simian Immunodeficiency Virus Infection of Rhesus Macaques, whereas an Added Vaccine Component Elicits Mixed Outcomes. J Immunol. 2020 Jun 15;204(12):3315-3328.  [Content Brief]

  [2]. Miller Jenkins LM, et al. Small-molecule inactivation of HIV-1 NCp7 by repetitive intracellular acyl transfer. Nat Chem Biol. 2010 Dec;6(12):887-9.  [Content Brief]

  [3]. Cheng-Mayer C, et al. Delay of simian human immunodeficiency virus infection and control of viral replication in vaccinated macaques challenged in the presence of a topical microbicide. AIDS. 2011 Sep 24;25(15):1833-41.  [Content Brief]