Sanggenon G 

Sanggenon G is a cell-permeable and potent inhibitor of X-linked inhibitor of apoptosis protein (XIAP). Sanggenon G binds specifically to the BIR3 domain of XIAP with a binding affinity of 34.26 μM. Sanggenon G enhances caspase activation^[1].

Sanggenon G (14.4 μM, 24 h) enhances caspase-8, -3 and -9 cleavage, displaces caspase-9 from XIAP and sensitizes Molt3/XIAP cells to Etoposide (HY-13629)-induced apoptosis^[1].
Sanggenon G not only sensitizes the XIAP-overexpressing leukemia cell line Molt3/XIAP to Etoposide (HY-13629) treatment but also different neuroblastoma cell lines endogenously expressing high XIAP levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

694.72

C₄₀H₃₈O₁₁

85698-31-3

Solid

White to off-white

O=C1C[C@@H](C2=CC=C(O)C=C2O)OC3=CC(O)=C([C@H]4C=C(CC/C=C(C)/C)C[C@@H](C5=CC=C(O)C=C5O)[C@@H]4C(C6=CC=C(O)C=C6O)=O)C(O)=C13

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

• [1]. Seiter MA, et al. Discovery of Sanggenon G as a natural cell-permeable small-molecular weight inhibitor of X-linked inhibitor of apoptosis protein (XIAP). FEBS Open Bio. 2014 Jul 5;4:659-71.  [Content Brief]