Santamarine (Synonyms: Santamarin; Balchanin)

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Santamarine (Santamarin), a sesquiterpene lactone, increases HO-1 expression through Nrf2 translocation and suppresses NO, PGE2, TNF-α, and IL-1β production through inhibition of NF-κB translocation in LPS-induced macrophages. Santamarine shows anti-photoaging properties via inhibition of MAPK/AP-1 and stimulation of TGF-β/Smad signaling in UVA-irradiated human dermal fibroblasts (HDFs). Antioxidant activities.

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Santamarine Chemical Structure

CAS No. : 4290-13-5

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	IC₅₀	0.16 μg/mL Compound: 1; STM	Growth inhibition of human CCRF-CEM cells incubated for 24 to 48 hrs by trypan blue exclusion assay Growth inhibition of human CCRF-CEM cells incubated for 24 to 48 hrs by trypan blue exclusion assay	[PMID: 33775837]
KB	IC₅₀	0.16 μg/mL Compound: 1; STM	Growth inhibition of human KB cells incubated for 72 hrs by methylene blue staining based assay Growth inhibition of human KB cells incubated for 72 hrs by methylene blue staining based assay	[PMID: 33775837]
L1210	IC₅₀	0.16 μg/mL Compound: 1; STM	Growth inhibition of mouse L1210 cells incubated for 24 to 48 hrs by trypan blue exclusion assay Growth inhibition of mouse L1210 cells incubated for 24 to 48 hrs by trypan blue exclusion assay	[PMID: 33775837]
LS174T	IC₅₀	0.16 μg/mL Compound: 1; STM	Growth inhibition of human LS174T cells incubated for 72 hrs by methylene blue staining based assay Growth inhibition of human LS174T cells incubated for 72 hrs by methylene blue staining based assay	[PMID: 33775837]
LX-2	IC₅₀	> 60 μM Compound: 1; STM	Inhibition of hyaluronic acid deposition in human LX2 cells incubated for 72 hrs by ELISA Inhibition of hyaluronic acid deposition in human LX2 cells incubated for 72 hrs by ELISA	[PMID: 33775837]
LX-2	IC₅₀	16.5 μM Compound: 1; STM	Cytotoxicity against human LX2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human LX2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 33775837]
LX-2	IC₅₀	18.6 μM Compound: 1; STM	Inhibition of laminin deposition in human LX2 cells incubated for 72 hrs by ELISA Inhibition of laminin deposition in human LX2 cells incubated for 72 hrs by ELISA	[PMID: 33775837]
LX-2	IC₅₀	7.3 μM Compound: 1; STM	Inhibition of collagen type 1 deposition in human LX2 cells incubated for 72 hrs by ELISA Inhibition of collagen type 1 deposition in human LX2 cells incubated for 72 hrs by ELISA	[PMID: 33775837]
MCF7	IC₅₀	0.16 μg/mL Compound: 1; STM	Growth inhibition of human MCF7 cells incubated for 72 hrs by methylene blue staining based assay Growth inhibition of human MCF7 cells incubated for 72 hrs by methylene blue staining based assay	[PMID: 33775837]
Platelet	IC₅₀	84.93 μM Compound: Santamarin	Antimigraine activity in bovine citreated platelet assessed as inhibition of [14C]serotonin release after 6 mins by scintillation counting Antimigraine activity in bovine citreated platelet assessed as inhibition of [14C]serotonin release after 6 mins by scintillation counting	[PMID: 1431933]
T-cell	IC₅₀	19.6 μM Compound: 7	Immunosuppressant activity in human T lymphocytes assessed as inhibition of anti-human CD3 and anti-human CD28 monoclonal antibody-induced T lymphocyte proliferation incubated for 72 hrs by FACS analysis Immunosuppressant activity in human T lymphocytes assessed as inhibition of anti-human CD3 and anti-human CD28 monoclonal antibody-induced T lymphocyte proliferation incubated for 72 hrs by FACS analysis	[PMID: 31181920]

Molecular Weight

248.32

Formula

C₁₅H₂₀O₃

CAS No.

4290-13-5

SMILES

O=C(O[C@@]1([H])[C@@]2([H])CC[C@@]3(C)[C@H](O)CC=C(C)[C@@]31[H])C2=C

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Choi HG, et al. Santamarin, a sesquiterpene lactone isolated from Saussurea lappa, represses LPS-induced inflammatory responses via expression of heme oxygenase-1 in murine macrophage cells. Int Immunopharmacol. 2012;13(3):271-279. [Content Brief]

[2]. Oh JH, et al. Santamarine Shows Anti-Photoaging Properties via Inhibition of MAPK/AP-1 and Stimulation of TGF-β/Smad Signaling in UVA-Irradiated HDFs. Molecules. 2021;26(12):3585. Published 2021 Jun 11. [Content Brief]

Santamarine Related Classifications

Inflammation/Immunology

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Santamarine4290-13-5Santamarin BalchaninKeap1-Nrf2anti-photoaginginflammatory responsesheme oxygenase-1human dermal fibroblastsantioxidantInhibitorinhibitorinhibit

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