2. Anti-infection
  3. Parasite
  4. SAR 97276

SAR 97276  (Synonyms: Albitiazolium bromide)

Cat. No.: HY-14830 Purity: 98.05%
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SAR 97276 (Albitiazolium bromide) is an antimalarial agent. SAR 97276 interfers with the phospholipid metabolism of malarial parasites, especially the biosynthesis of phosphatidylcholine (PC). SAR 97276 enters erythrocytes through the new permeability pathways (NPP) of infected erythrocytes, and is transported into the malarial parasite by a poly-specific cation carrier.

For research use only. We do not sell to patients.

SAR 97276 Chemical Structure

SAR 97276 Chemical Structure

CAS No. : 321915-72-4

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SAR 97276 Related Antibodies

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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Description

SAR 97276 (Albitiazolium bromide) is an antimalarial agent. SAR 97276 interfers with the phospholipid metabolism of malarial parasites, especially the biosynthesis of phosphatidylcholine (PC). SAR 97276 enters erythrocytes through the new permeability pathways (NPP) of infected erythrocytes, and is transported into the malarial parasite by a poly-specific cation carrier[1].

Cellular Effect
Cell Line Type Value Description References
Jurkat IC50
347 μM
Compound: T3
Cytotoxicity against human Jurkat cells after 24 hrs by [3H]thymidine incorporation assay
Cytotoxicity against human Jurkat cells after 24 hrs by [3H]thymidine incorporation assay
[PMID: 23289711]
Molecular Weight

614.54

Synonyms

Albitiazolium bromide

Formula

C24H42Br2N2O2S2
CAS No.
Appearance

Solid

Color

Off-white to light brown

SMILES

OCCC1=C(C)[N+](CCCCCCCCCCCC[N+]2=CSC(CCO)=C2C)=CS1.[Br-].[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (162.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6272 mL 8.1362 mL 16.2723 mL
5 mM 0.3254 mL 1.6272 mL 3.2545 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6272 mL 8.1362 mL 16.2723 mL 40.6808 mL
5 mM 0.3254 mL 1.6272 mL 3.2545 mL 8.1362 mL
10 mM 0.1627 mL 0.8136 mL 1.6272 mL 4.0681 mL
15 mM 0.1085 mL 0.5424 mL 1.0848 mL 2.7121 mL
20 mM 0.0814 mL 0.4068 mL 0.8136 mL 2.0340 mL
25 mM 0.0651 mL 0.3254 mL 0.6509 mL 1.6272 mL
30 mM 0.0542 mL 0.2712 mL 0.5424 mL 1.3560 mL
40 mM 0.0407 mL 0.2034 mL 0.4068 mL 1.0170 mL
50 mM 0.0325 mL 0.1627 mL 0.3254 mL 0.8136 mL
60 mM 0.0271 mL 0.1356 mL 0.2712 mL 0.6780 mL
80 mM 0.0203 mL 0.1017 mL 0.2034 mL 0.5085 mL
100 mM 0.0163 mL 0.0814 mL 0.1627 mL 0.4068 mL
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SAR 97276 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SAR 97276321915-72-4AlbitiazoliumSAR97276SAR-97276ParasiteP. falciparumantimalarialInhibitorinhibitorinhibit

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