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  4. SAR 97276

SAR 97276 (Albitiazolium bromide) is an antimalarial agent. SAR 97276 interfers with the phospholipid metabolism of malarial parasites, especially the biosynthesis of phosphatidylcholine (PC). SAR 97276 enters erythrocytes through the new permeability pathways (NPP) of infected erythrocytes, and is transported into the malarial parasite by a poly-specific cation carrier.

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SAR 97276 Chemical Structure

SAR 97276 Chemical Structure

CAS No. : 321915-72-4

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SAR 97276 Related Antibodies

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Description

SAR 97276 (Albitiazolium bromide) is an antimalarial agent. SAR 97276 interfers with the phospholipid metabolism of malarial parasites, especially the biosynthesis of phosphatidylcholine (PC). SAR 97276 enters erythrocytes through the new permeability pathways (NPP) of infected erythrocytes, and is transported into the malarial parasite by a poly-specific cation carrier[1].

Cellular Effect
Cell Line Type Value Description References
Jurkat IC50
347 μM
Compound: T3
Cytotoxicity against human Jurkat cells after 24 hrs by [3H]thymidine incorporation assay
Cytotoxicity against human Jurkat cells after 24 hrs by [3H]thymidine incorporation assay
[PMID: 23289711]
Molecular Weight

614.54

Formula

C24H42Br2N2O2S2
CAS No.
SMILES

OCCC1=C(C)[N+](CCCCCCCCCCCC[N+]2=CSC(CCO)=C2C)=CS1.[Br-].[Br-]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SAR 97276 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SAR 97276321915-72-4AlbitiazoliumSAR97276SAR-97276ParasiteP. falciparumantimalarialInhibitorinhibitorinhibit

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