2. Metabolic Enzyme/Protease Membrane Transporter/Ion Channel Neuronal Signaling
  3. Endogenous Metabolite GlyT
  4. Sarcosine-15N

Sarcosine-15N  (Synonyms: N-Methylglycine-15N; Sarcosin-15N)

Cat. No.: HY-101037S Purity: ≥99.0%
SDS COA Handling Instructions

Molarity Calculator

Sarcosine-15N is the 15N-labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia[1][2].

For research use only. We do not sell to patients.

Sarcosine-<sup>15</sup>N Chemical Structure

Sarcosine-15N Chemical Structure

Size Price Stock Quantity
1 mg USD 140 In-stock
5 mg USD 490 In-stock
10 mg USD 780 In-stock
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of Sarcosine-15N:

Sarcosine-15N Related Antibodies

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GlyT1 GlyT2

  • Biological Activity

  • Purity & Documentation

  • References

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Description

Sarcosine-15N is the 15N-labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia[1][2].

IC50 & Target

GlyT1

 

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sarcosine-15N Related Antibodies
Molecular Weight

90.09

Formula

C3H715NO2
Unlabeled CAS

107-97-1
Appearance

Solid

Color

White to off-white

SMILES

O=C(C[15NH]C)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (1110.00 mM; Need ultrasonic)

H2O : 100 mg/mL (1110.00 mM; Need ultrasonic)

DMSO : 1 mg/mL (11.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 1 mg/mL (11.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 11.1000 mL 55.5001 mL 111.0001 mL
5 mM 2.2200 mL 11.1000 mL 22.2000 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥99.0%

SDS (251 KB)

COA (244 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO / H2O / H2O 1 mM 11.1000 mL 55.5001 mL 111.0001 mL 277.5003 mL
5 mM 2.2200 mL 11.1000 mL 22.2000 mL 55.5001 mL
10 mM 1.1100 mL 5.5500 mL 11.1000 mL 27.7500 mL
H2O / H2O 15 mM 0.7400 mL 3.7000 mL 7.4000 mL 18.5000 mL
20 mM 0.5550 mL 2.7750 mL 5.5500 mL 13.8750 mL
25 mM 0.4440 mL 2.2200 mL 4.4400 mL 11.1000 mL
30 mM 0.3700 mL 1.8500 mL 3.7000 mL 9.2500 mL
40 mM 0.2775 mL 1.3875 mL 2.7750 mL 6.9375 mL
50 mM 0.2220 mL 1.1100 mL 2.2200 mL 5.5500 mL
60 mM 0.1850 mL 0.9250 mL 1.8500 mL 4.6250 mL
80 mM 0.1388 mL 0.6938 mL 1.3875 mL 3.4688 mL
100 mM 0.1110 mL 0.5550 mL 1.1100 mL 2.7750 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Sarcosine-15N Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sarcosine-15NN-Methylglycine-15NSarcosin-15NEndogenous MetaboliteGlyTGlycine transportersInhibitorinhibitorinhibit

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