SARS-CoV-2-IN-26

Cat. No.: HY-151269: FAQs
Data Sheet Handling Instructions

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SARS-CoV-2-IN-23 is a two-armed diphosphate ester and medium length molecular tweezers. SARS-CoV-2-IN-23 exhibits antiviral activity with IC₅₀s of 8.2 μM and 2.6 μM against SARS-CoV-2 activity and the spike pseudoparticle transduction, respectively. SARS-CoV-2-IN-23 induces liposomal membrane disruption with an EC₅₀ value of 4.4 μM.

For research use only. We do not sell to patients.

SARS-CoV-2-IN-26 Chemical Structure

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This product is a controlled substance and not for sale in your territory.

Other Forms of SARS-CoV-2-IN-26:

SARS-CoV-2-IN-23 Get quote
SARS-CoV-2-IN-23 disodium Get quote

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•Related Small Molecules:

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

IC50: 4.4 μM (viral liposome, SARS-CoV-2)^[1]

In Vitro

SARS-CoV-2-IN-23 (CP002) inhibits SARS-CoV-2 (IC₅₀=2.6 μM) with a low cytotoxicity (Caco2 cells, CC₅₀=97 μM)^[1].
SARS-CoV-2-IN-23 (0-15 μM; 2 h) inactivate SARS-CoV-2, shows inhibition against infection with an IC₅₀ value of 8.2 μM^[1].
SARS-CoV-2-IN-23 suppresses varies enveloped viruses activity with IC₅₀s of 38.4 μM (influenza A virus, IAV), 2.8 μM (measles virus, MeV), 1.1 μM (herpes simplex viruses, HSV-1), and human immunodeficiency virus type 1 (HIV-1), respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	Caco2 cells exposed with SARS-CoV-2 (2 h, 37 ℃)
Concentration:	0, 0.23, 0.93, 3.75, 15 μM
Incubation Time:	2 hours; determined infection rates on day 2
Result:	Inhibited SARS-CoV-2 infection activity to Caco2 cells.

Molecular Weight

866.91

Formula

C₅₂H₅₂O₈P₂

SMILES

CC(CCOP(OC1=C2C(C3C4=C(C2C3)C=C5C(C6C7=C(C5C6)C=CC=C7)=C4)=C(C8=C1C9C%10=CC(C%11CC%12C%13=C%11C=CC=C%13)=C%12C=C%10C8C9)OP(OCCC(C)C)(O)=O)(O)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tatjana Weil, et al. Advanced Molecular Tweezers with Lipid Anchors against SARS-CoV-2 and Other Respiratory Viruses. JACS Au 2022, XXXX, XXX, XXX-XXX.

SARS-CoV-2-IN-26 Related Classifications

Infection

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SARS-CoV-2-IN-26SARS-CoVSARS coronavirusbroad-spectrum antiviralsSARS-CoV-2RSVmolecular tweezersrespiratory virusesliposometwo-armed diphosphate esterinfluenza A virusIAVmeasles virusMeVherpes simplex virusesHSV-1Inhibitorinhibitorinhibit

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