SARS-CoV-2-IN-32

Cat. No.: HY-151477: FAQs
Data Sheet Handling Instructions

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SARS-CoV-2-IN-32 (compound 3g) is a COVID-19 inhibitor. SARS-CoV-2-IN-32 shows anti-proliferative activity against cancer cells. SARS-CoV-2-IN-32 exhibits comparatively high binding affinity (-8.8 Kcal/mole) to COVID-19 main protease (M^pro) (PDB ID: 6LU7). SARS-CoV-2-IN-32 can be used in studies of cancer and COVID-19.

For research use only. We do not sell to patients.

SARS-CoV-2-IN-32 Chemical Structure

CAS No. : 96068-42-7

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Description

IC₅₀ & Target

COVID-19^[1].

In Vitro

SARS-CoV-2-IN-32 (0-40 µM; 48 h) exhibits antiproliferative activity in MCF-7, MDA-MB-231, HeLa and PC-3 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	MCF-7, MDA-MB-231, HeLa, PC-3, Ishikawa, HEK-293
Concentration:	0-40 µM
Incubation Time:	48 h
Result:	Inhibited proliferation of MCF-7, MDA-MB-231, HeLa, PC-3, Ishikawa, HEK-293 cells with IC₅₀ values of 35.64, 39.56, 38.32, 35.38, >40 and >40 μM, respectively.

Molecular Weight

481.50

Formula

C₂₇H₂₃N₅O₄

CAS No.

96068-42-7

SMILES

[O-][N+](C1=CC=C(C(C2=C(N(C3=CC=CC=C3)N=C2C)O)C4=C(N(C5=CC=CC=C5)N=C4C)O)C=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gupta A, et al. Visible Light-Promoted Green and Sustainable Approach for One-Pot Synthesis of 4, 4’-(Arylmethylene) bis (1H-pyrazol-5-ols), In Vitro Anticancer Activity, and Molecular Docking with Covid-19 Mpro. ACS Omega, 2022.

SARS-CoV-2-IN-32 Related Classifications

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SARS-CoV-2-IN-3296068-42-7SARS-CoVSARS coronaviruscancerMCF-7MDA-MB-231HeLaPC-3IshikawaHEK-293Inhibitorinhibitorinhibit

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