SARS-CoV-2-IN-33

Cat. No.: HY-151478: FAQs
Data Sheet Handling Instructions

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SARS-CoV-2-IN-33 (compound 3m) is a COVID-19 inhibitor. SARS-CoV-2-IN-33 shows anti-proliferative activity against cancer cells. SARS-CoV-2-IN-33 exhibits comparatively good binding affinity (-8.0 Kcal/mole) to COVID-19 main protease (M^pro) (PDB ID: 6LU7). SARS-CoV-2-IN-33 can be used in studies of cancer and COVID-19.

For research use only. We do not sell to patients.

SARS-CoV-2-IN-33 Chemical Structure

CAS No. : 299919-79-2

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Description

IC₅₀ & Target

COVID-19^[1].

In Vitro

SARS-CoV-2-IN-33 (0-40 µM) exhibits good antiproliferative activity in MCF-7, MDA-MB-231, HeLa and PC-3 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	MCF-7, MDA-MB-231, HeLa, PC-3, Ishikawa, HEK-293
Concentration:	0-40 µM
Incubation Time:	48 h
Result:	Inhibited proliferation of MCF-7, MDA-MB-231, HeLa, PC-3, Ishikawa, HEK-293 cells with IC₅₀ values of 5.45, 9.47, 22.86, 28.44, >40 and >40 μM, respectively.

Molecular Weight

526.58

Formula

C₃₀H₃₀N₄O₅

CAS No.

299919-79-2

SMILES

OC1=C(C(C2=C(N(C3=CC=CC=C3)N=C2C)O)C4=CC(OC)=C(C(OC)=C4)OC)C(C)=NN1C5=CC=CC=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gupta A, et al. Visible Light-Promoted Green and Sustainable Approach for One-Pot Synthesis of 4, 4’-(Arylmethylene) bis (1H-pyrazol-5-ols), In Vitro Anticancer Activity, and Molecular Docking with Covid-19 Mpro. ACS Omega, 2022.

SARS-CoV-2-IN-33 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SARS-CoV-2-IN-33299919-79-2SARS-CoVSARS coronaviruscancerMCF-7MDA-MB-231HeLaPC-3IshikawaHEK-293Inhibitorinhibitorinhibit

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