SARS-CoV-2-IN-55 

SARS-CoV-2-IN-55(compound 65) is a low cytotoxicity inhibtor of SARS-CoV-2 with an IC₅₀ value of 0.3 μM, by the direct interaction with VSV-S pseudoparticles^[1].

IC50: 0.3 μM (SARS-CoV-2)^[1]

SARS-CoV-2-IN-55 (10 μM, 24 h) inhibits the viral activity of SARS-CoV-2 in Vero E6 cell and A549-ACE2-TMPRSS2 cell respectively with the IC₅₀ value of 0.3 μM and 15.8 μM, meanwhile inhibits the viral activity of Wuhan-Hu-1 (IC₅₀=0.28 μM) and Omicron BA.1 (IC₅₀=6.24 μM) in Vero E6-TMPRSS2 cell^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2807.07

C₁₃₈H₁₃₆N₂₂O₃₂S₆

O=C(NC(CC1=C(SC2=CC=C(C=C2)[N+]([O-])=O)NC3=CC=CC=C31)C=O)CCC(CCC(NC(C=O)CC4=C(NC5=C4C=CC=C5)SC6=CC=C(C=C6)[N+]([O-])=O)=O)(NC(CNC(CCOCCOCCOCCOCCC(NCC(NC(CCC(NC(C=O)CC7=C(NC8=C7C=CC=C8)SC9=CC=C(C=C9)[N+]([O-])=O)=O)(CCC(NC(C=O)CC%10=C(NC%11=C%10C=CC=C%11)SC%12=CC=C(C=C%12)[N+]([O-])=O)=O)CCC(NC(CC%13=C(NC%14=C%13C=CC=C%14)SC%15=CC=C(C=C%15)[N+]([O-])=O)C=O)=O)=O)=O)=O)=O)CCC(NC(CC%16=C(NC%17=C%16C=CC=C%17)SC%18=CC=C(C=C%18)[N+]([O-])=O)C=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Marta Gargantilla, et al. C‑2 Thiophenyl Tryptophan Trimers Inhibit Cellular Entry of SARSCoV‑2 through Interaction with the Viral Spike (S) Protein. J Med Chem. 2023.  [Content Brief]