2. Apoptosis Stem Cell/Wnt TGF-beta/Smad
  3. Organoid Apoptosis TGF-β Receptor
  4. SB-431542 (Standard)

SB-431542 (Standard) is the analytical standard of SB-431542. SB-431542 is a TGF-β receptor kinase inhibitor (TRKI). SB-431542 has inhibitory activity for ALK4, ALK5 and ALK7 with IC50 values of 1 μM, 0.75 μM and 2 μM, respectively. SB-431542 also inhibits TGF-β-induced transcription, gene expression, apoptosis, and growth suppression. SB-431542 can be used for the research of cancer and signal transduction pathways.

For research use only. We do not sell to patients.

SB-431542 (Standard) Chemical Structure

SB-431542 (Standard) Chemical Structure

CAS No. : 301836-41-9

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Description
Molecular Weight

384.39

Formula

C22H16N4O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CC=C(C=C1)C2=NC(C3=CC=C4OCOC4=C3)=C(N2)C5=NC=CC=C5)N
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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SB-431542 (Standard) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SB-431542 (Standard)301836-41-9OrganoidApoptosisTGF-β ReceptorTransforming growth factor beta receptorsTGF-β receptor kinase inhibitor (TRKI)ALK4ALK5ALK7transcriptiongene expressionapoptosisgrowth suppressioncancersignal transduction pathwaysInhibitorinhibitorinhibit

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