2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. SB26019

SB26019 is a potent anti-neuroinflammatory agent. SB26019 regulates NF-κB activation by inducing monomeric α-tubulin formation. SB26019-induced α-tubulin monomer inhibits p65 translocation.

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SB26019 Chemical Structure

SB26019 Chemical Structure

CAS No. : 1233078-90-4

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SB26019 Related Antibodies

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Description

SB26019 is a potent anti-neuroinflammatory agent. SB26019 regulates NF-κB activation by inducing monomeric α-tubulin formation. SB26019-induced α-tubulin monomer inhibits p65 translocation[1].

In Vitro

SB26019 (10 μM; for 6 h) suppresses the production of inflammatory marker genes, such as Ccl2, Cxcl10, Il-1β, Il-6, Nos2, and Tnf[1].
SB26019 (1.25-10 μM; 1-12 h) induces IκB degradation in a time- and dose-dependent manner[1].
SB26019 (IC50 of 1.13 μM) produces more significant amounts of α-tubulin monomers and fewer tubulin polymers than the less potent anti-inflammatory regulator colchicine (IC50 of 4.20 μM)[1].
SB26019 (10 μM)-induced α-tubulin monomer inhibits p65 translocation in J774A.1 and RAW264.7 murine macrophage cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SB26019 Related Antibodies

RT-PCR[1]

Cell Line: BV-2 murine microglial cells
Concentration: 10 μM
Incubation Time: 6 h
Result: Suppressed the production of inflammatory marker genes.

Western Blot Analysis[1]

Cell Line: J774A.1 cells
Concentration: 1.25 μM, 2.5 μM, 5 μM, 10 μM
Incubation Time: 1 h, 3 h, 6 h, 12 h
Result: Dose- and time-dependent IκB degradation without affecting the total amount of p65 in J774A.1 cells.
In Vivo

SB26019 (2-5 mg/kg; i.p; daily; for 4 days) ameliorates neuroinflammation in vivo[1].
Pharmacokinetic (PK) analysis of SB26019[1].

Parameters I.P.,5 mg/kg
Tmax (h) 0.17 ± 0.00
Cmax (μg/mL) 1.20 ± 0.26
T1/2 (h) 3.57 ± 0.62
AUCt (μg h/mL) 1.77 ± 0.30
AUC∞ (μg h/mL) 1.79 ± 0.31
CL (L/h/kg) NA
Vss (L/kg) NA
Ft (%) NA

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 10-week-old female C57BL/6 mice (20-25 g)[1]
Dosage: 2 mg/kg, 5 mg/kg
Administration: i.p; daily; for 4 days
Result: Suppressed microglial activation by downregulating lba-1 and proinflammatory cytokines.
Molecular Weight

372.41

Formula

C24H20O4
CAS No.
SMILES

COC1=CC=C2C(C3=C4OC5=C(C4=CC=C3)C=CC=C5)=CC(C)(OC2=C1O)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SB26019 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SB260191233078-90-4SB 26019SB-26019Microtubule/Tubulinanti-neuroinflammatory activityp65NF-κBα-tubulinlba-1Inhibitorinhibitorinhibit

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