2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. SB399885

SB399885 is a potent, selective, brain penetrant and orally active 5-HT6 receptor antagonist with pKi values 9.11 and 9.02 for human recombinant and native 5-HT6 receptors, respectively. SB399885 has cognitive enhancing properties.

For research use only. We do not sell to patients.

SB399885 Chemical Structure

SB399885 Chemical Structure

CAS No. : 402713-80-8

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Based on 1 publication(s) in Google Scholar

Other Forms of SB399885:

SB399885 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE SB399885

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Description

SB399885 is a potent, selective, brain penetrant and orally active 5-HT6 receptor antagonist with pKi values 9.11 and 9.02 for human recombinant and native 5-HT6 receptors, respectively. SB399885 has cognitive enhancing properties[1].

IC50 & Target[1]

5-HT6 Receptor

9.02 (pKi)

Human 5-HT6 Receptor

9.11 (pKi)

Molecular Weight

446.35

Formula

C18H21Cl2N3O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC1=C(N2CCNCC2)C=C(S(NC3=C(C(Cl)=CC(Cl)=C3)OC)(=O)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 4.17 mg/mL (9.34 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2404 mL 11.2020 mL 22.4039 mL
5 mM 0.4481 mL 2.2404 mL 4.4808 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2404 mL 11.2020 mL 22.4039 mL 56.0099 mL
5 mM 0.4481 mL 2.2404 mL 4.4808 mL 11.2020 mL
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SB399885 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SB399885402713-80-8SB 399885SB-3998855-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptorselectivebrain penetrantorally activecognitive enhancing propertiesInhibitorinhibitorinhibit

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